Clinical Trials in Philadelphia

Showing 13661-13680 of 20,904 trials

A Study Evaluating the Safety and Efficacy of the LentiGlobin BB305 Drug Product in β-Thalassemia Major Participants

NCT01745120

This is a non-randomized, open label, multi-site, single-dose, phase 1/2 study in up to 18 participants (including at least 3 adolescents between 12 and 17 years of age, inclusive) with β-thalassemia major. The study will evaluate the safety and efficacy of autologous hematopoietic stem cell transplantation (HSCT) using LentiGlobin BB305 Drug Product \[autologous CD34+ hematopoietic stem cells transduced with LentiGlobin BB305 lentiviral vector encoding the human βA-T87Q-globin gene\].

β-thalassemia Major

Genetix Biotherapeutics Inc.19 participantsStarted Aug 2013

Los Angeles, California, United States • Oakland, California, United States • Chicago, Illinois, United States +3 more locations

UNKNOWN< 1 mile

NGS for Non-unions

NCT03937310

The purpose of this study is to investigate the role of genetic testing to look for possible infection as a cause for failure of non-healing fractures. The study aims to compare the results of genetic testing known as NGS to standardized clinical laboratory tests for diagnosing infections to see if NGS may be a better diagnostic tool.

Nonunion of Fracture

Rothman Institute Orthopaedics120 participantsStarted Jan 2019

Philadelphia, Pennsylvania, United States

TERMINATEDEARLY Phase 1< 1 mile

Dosing of Amicar and Measure of Fibrinolysis by TEG During Cardiac Surgery

NCT01965730

This study hopes to determine the optimal antifibrinolytic dosing to decrease bleeding and blood transfusion after cardiac surgery without increasing adverse events

Aortic Disease

University of Pennsylvania8 participantsStarted Jan 2013

Philadelphia, Pennsylvania, United States

A Study Evaluating the Safety and Efficacy of the LentiGlobin BB305 Drug Product in β-Thalassemia Major Participants

NGS for Non-unions

Dosing of Amicar and Measure of Fibrinolysis by TEG During Cardiac Surgery

Find Trials by Condition in Philadelphia

The Evaluation of Bococizumab (PF-04950615; RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Modulation of Monocyte Activation by Atorvastatin in HIV Infection

Melody® Transcatheter Pulmonary Valve Post-Approval Study

Transcorneal Electrical Stimulation for the Treatment of Retinitis Pigmentosa - a Safety and Efficacy Multicenter Study

A Study of the Efficacy and Safety of a 3-month Treatment Course of Ulipristal Acetate for the Treatment of Abnormal Uterine Bleeding Associated With Leiomyomas

A Phase2 of A-101 Topical Solution in Subjects With Common Warts

Safety and Tolerability of Tozadenant as Adjunctive Therapy in Levodopa-Treated Patients With Parkinson's Disease.

Videogame-based Incentives for Smoking Cessation

Renal Effects of Three Iodinated Contrast Media (CM) in Patients at Risk Undergoing Coronary Angiography

Study To Evaluate Pf-04965842 In Subjects With Moderate To Severe Atopic Dermatitis

Long-term Safety and Efficacy of Sirukumab in Participants With RA Completing Studies CNTO136ARA3002 or CNTO136ARA3003

A Study to Investigate the Safety and Efficacy of Lacosamide Added to the Patients Current Therapy in Patients Aged 1 Month to Less Than 18 Years Old With Epilepsy Syndromes Associated With Generalized Seizures.

Sodium Management in Acute Neurological Injury

MEmbranous Nephropathy Trial Of Rituximab

A Phase 1 First-in-Human Study Evaluating AMG 900 in Advanced Solid Tumors

Operative Versus Nonoperative Treatment of Humeral Shaft Fractures: A Prospective Cohort Comparison Study

A Study to Evaluate the Safety and Effectiveness of Oculeve Intranasal Lacrimal Neurostimulator in Participants With Dry Eye Syndrome