Clinical Trials in Philadelphia

Showing 13681-13700 of 20,904 trials

Sorafenib for Hepatopulmonary Syndrome

NCT02021929

The main purpose of this clinical trial is to determine the safety and effects of the study drug, sorafenib, in adults diagnosed with hepatopulmonary syndrome (HPS). The study will evaluate how well the drug is tolerated and its effect on the level of oxygen in the blood and the function of the lung vessels.

Hepatopulmonary Syndrome

University of Pennsylvania28 participantsStarted Mar 2014

Phoenix, Arizona, United States • Chicago, Illinois, United States • Rochester, Minnesota, United States +4 more locations

COMPLETEDPhase 1< 1 mile

Study of RXDX-105, Potent RET Inhibitor in Patients With Advanced Lung Cancer and Other Solid Tumors

NCT01877811

This is a first-in-human, multicenter, open-label study consisting of 2 phases. Phase 1 is a dose escalation study of RXDX-105 (formerly known as CEP-32496) in patients with advanced solid tumors aimed at defining the recommended Phase 2 dose (RP2D) and schedule for administration. Phase 1b is a dose expansion in approximately 90 patients with advanced solid tumors with specific histologies and/or molecular alterations of interest. Patients in Phase 1b will be treated at the RP2D determined in Phase 1.

Solid Tumors

Hoffmann-La Roche143 participantsStarted Jun 2013

Duarte, California, United States • Irvine, California, United States • San Diego, California, United States +11 more locations

Sorafenib for Hepatopulmonary Syndrome

Study of RXDX-105, Potent RET Inhibitor in Patients With Advanced Lung Cancer and Other Solid Tumors

Find Trials by Condition in Philadelphia

Safety and Efficacy of Tafamidis in Patients With Transthyretin Cardiomyopathy

Photodynamic Therapy in Treating Patients With Premalignant or Early Stage Head and Neck Tumors

Nelfinavir Mesylate, Radiation Therapy, and Temozolomide in Treating Patients With Glioblastoma Multiforme

Proton Therapy for High Risk Prostate Cancer

Videogame-based Incentives for Smoking Cessation

Mitochondrial Oxidative Stress and Vascular Health in Chronic Kidney Disease

Induction of Labor With Oxytocin: When Should Oxytocin be Held?

The Respiratory Protection Effectiveness Clinical Trial

Safety and Tolerability Study of MDV3100 in Combination With Docetaxel in Men With Advanced Prostate Cancer

Prevention of Transfusion Related Acute Gut Injury (TRAGI) in Extremely Low Gestational Age Neonates (ELGANs) Using iNO

Ketamine for Major Depressive Disorder

A Study to Evaluate the Safety and Effectiveness of Oculeve Intranasal Lacrimal Neurostimulator in Participants With Dry Eye Syndrome

A Study of Nivolumab Safety and Pharmacokinetics in Patients With Severe Sepsis or Septic Shock.

Topical Bimatoprost in the Treatment of Migraine

Inhaled Prostaglandin E1 (IPGE1) for Hypoxemic Respiratory Failure (NHRF)

A Study Evaluating the Efficacy and Safety of BOTOX® or Solifenacin in Patients With Overactive Bladder and Urinary Incontinence

A Study of the Safety and Efficacy of a New Treatment for Macular Edema Resulting From Retinal Vein Occlusion

Safety and Efficacy of a New Treatment as Adjunctive Therapy to Anti-vascular Endothelial Growth Factor (Anti-VEGF) Treatment in Patients With Age-Related Macular Degeneration (AMD)