Study of Effectiveness of GEMDOX in Relapsed Osteosarcoma

Inclusion Criteria

• •Age at diagnosis of high grade osteosarcoma \>= 4
• •Received first line treatment with HD IFO
• •Following HD IFO treatment, they have been diagnosed refractory disease and they satisfy at least one of the following criteria :
• •1. Relapsed in the first 24 month following the initial diagnosis, regardless of location and resectability
• •2. Lung relapsed disease with more than 2 nodules diagnosed over 24 months from the initial diagnosis
• •3. Non resectable relapsed disease diagnosed over 24 months from the initial diagnosis Before or during GEMDOX treatment, eligible patients may have been subject to metastasectomy