Lead Sponsor

Peking University People's Hospital

Collaborators

Age

All ages

Sex

ALL

Healthy Volunteers

No

•Histologically confirmed high-grade osteosarcoma reviewed by the Pathology Committee of Peking University People's Hospital
•Pulmonary nodules by Chest CT confirmed by later scan as pulmonary metastasis
•A first complete remission (CR) had been achieved
•Intended first-line treatment included pre- and postoperative chemotherapy according to the PKUPH-OS protocol as well as local therapy of all operable lesions

•Lost to follow up
•Patients with severe or uncontrolled medical disorders that could jeopardize the outcomes of the study. These confounding conditions included, cardiac clinical symptoms or disease with left ventricular ejection fraction\<50%, and hypertension that could not be well controlled with antihypertensive drugs.