Inhalation SLIT Cisplatin (Liposomal) for the Treatment of Osteosarcoma Metastatic to the Lung

Exclusion Criteria

• •Grade 3 or higher painful neuropathy persisting after a prior platinum containing regimen
• •Patients who are pregnant or are of childbearing potential and not using methods to avoid pregnancy
• •Concurrent systemic chemotherapy
• •Greater than Grade 2 pulmonary toxicity
• •Pulmonary atelectasis
• •Reactive airway disease which has resulted in hospitalization within the last year or which requires daily treatment with bronchodilator therapy
• •Concurrent serious infections
• •Unstable or serious concurrent medical condition
• •Recent major surgery or thoracic radiation therapy or chemotherapy
• •Significant pulmonary fibrosis secondary to prior radiation
• •Major ventilatory distribution abnormalities
• •Osteosarcoma secondary to radiation or premalignant conditions
• •History of prior malignancy
• •Low grade osteosarcoma, parosteal or periosteal sarcoma