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Showing 1-20 of 779 trials
NCT07567937
Wrestling is a weight-classified sport in which athletes frequently apply rapid weight loss (RWL) strategies prior to competition. While the performance-related consequences of RWL have been widely investigated, its combined effects with exercise on hematological parameters and immune cell profiles remain insufficiently understood. Therefore, this study aims to examine the effects of short-term weight loss and exercise on whole blood cell parameters and lymphocyte subsets in elite wrestlers. Nine elite male wrestlers actively competing in the senior category (mean age: 22.90 ± 5.15 years; mean height: 1.75 m) voluntarily participated in this study. Athletes will achieve an average body mass reduction of 4.3% over a five-day period. Venous blood samples will be collected at 09:30 a.m. in a fasted state during two experimental phases: (1) Exercise-only phase, with blood sampling before and after exercise (BRWL1 and BRWL2); (2) Exercise plus weight loss phase, following the five-day weight loss period, with blood sampling before and after exercise (ARWL1 and ARWL2). Complete blood count parameters will be analyzed using an automated hematology analyzer, while lymphocyte subsets (CD3+, CD4+, CD8+, CD19+, CD16/56+) will be assessed by flow cytometry. Statistical analyses will be performed with a significance level set at p \< 0.05.
NCT07565168
This study aims to compare the effects of three different training intensity distribution (TID) models-polarized, threshold, and pyramidal-on physiological and performance adaptations in recreational distance runners. Twenty-four participants will be assigned to one of the three training interventions and will complete an 8-week structured running program based on the respective TID approach. The primary objective is to determine whether different TID models elicit distinct changes in key physiological markers and endurance performance. The study seeks to answer whether a specific intensity distribution strategy provides superior adaptations in recreational runners when training is prescribed over a controlled intervention period.
NCT07556965
The goal of this clinical trial is to learn whether an exercise- and mindfulness-based cognitive therapy intervention can improve physical and psychological symptoms in cancer patients with chemotherapy-induced peripheral neuropathy. It will also examine whether this intervention can improve quality of life. The main questions it aims to answer are: Can this intervention reduce physical symptoms related to chemotherapy-induced peripheral neuropathy? Can this intervention reduce psychological symptoms in affected patients? Can this intervention improve patients' quality of life? Participants will: Follow a structured program of regular exercise and mindfulness practice Undergo weekly assessments of symptom changes Keep records of their symptom changes during the intervention period
NCT07402902
The goal of this clinical trial is to learn if different forms of caffeine ingestion can influence fat oxidation during submaximal cycling exercise. The study will recruit healthy adults, both men and women, aged 18 to 50, who regularly perform aerobic exercise. The main questions it aims to answer are: * Does caffeine increase fat oxidation during one hour of cycling at the Fatmax intensity? * Do different forms of caffeine ingestion (capsule, coffee, chewing gum, or mouth rinse) differ in their effect on fat oxidation? * Do these caffeine forms alter total energy expenditure, cardiorespiratory response, or perceived exertion during exercise? * Are there differences in the occurrence or severity of side effects between caffeine administration methods? Researchers will compare each caffeine form to its corresponding placebo to determine their effects on fat oxidation and other physiological outcomes. Participants will: * Attend a pre-experimental session to determine their Fatmax intensity and VO₂max using an incremental cycling test * Perform eight experimental sessions, each consisting of one hour of cycling at Fatmax intensity * Receive caffeine or placebo via capsules, coffee, chewing gum, or mouth rinse according to a randomized, double-blind, crossover design * Be monitored for fat and carbohydrate oxidation, total energy expenditure, heart rate, and perceived exertion during exercise * Report any side effects immediately after the session and 24 hours later using a structured questionnaire All sessions will be conducted under controlled laboratory conditions with standardized protocols to ensure safety and reliable measurements.
NCT07528807
This observational study aims to investigate the relationship between exercise benefits and barriers, pain beliefs, and activity patterns in individuals experiencing musculoskeletal pain. Participants will complete questionnaires about their pain, exercise habits, and daily activity patterns. The study does not involve any interventions or treatments. The purpose is to better understand how beliefs and perceived barriers influence physical activity in people with musculoskeletal pain, which may help inform future strategies to improve exercise participation and overall well-being.
NCT07540858
In this study, we investigated the impact of a comprehensive microgreen and wheatgrass juice protocol on the miRNA response following a standardized EIMD model and whether microgreen consumption could modulate key miRNA markers of neuromuscular regeneration and metabolic adaptation, thereby offering a novel nutritional approach to enhancing holistic recovery in athletes.
NCT07522138
This study aims to test whether patients with Parkinson's disease can safely and effectively use a home-based exercise program guided by videos. Participants will follow video instructions for exercises at home while their movements are monitored by a camera, which provides real-time feedback. The study will check how well participants complete the exercises, their satisfaction with the program, and any changes in clinical function. The goal is to see if this type of home exercise can help patients increase their activity levels without significant side effects.
NCT07504003
During prolonged endurance exercise, certain physiological variables deteriorate depending on the duration of the exercise. Physiological resilience has therefore been defined as the ability to resist these changes and appears to be an important performance factor in endurance sports. For example, most studies in this field have investigated changes in cycling power output associated with the first ventilatory threshold (VT1), a marker of an individual's endurance capacity, after prolonged endurance exercise. To date, only two studies have examined the effects of training on resilience. The first compared the effectiveness of two training programs, one with low-intensity sessions and the other with high-intensity sessions, with no difference between the conditions. The second study showed that incorporating strength training into a running training program was more effective at improving resilience than running alone. However, the influence of training session duration on resilience remains unknown. Only one observational study has shown that in a group of runners of similar ability, those who were used to doing long sessions had better resilience than those who only did short sessions.
NCT07187349
The purpose of this study is to examine the usability and effectiveness of a stress management device during an academic exam period and asks the following questions: * To what extent is a resistance breathing device (AIRpen) utilized by participants during the study period? * What impact does utilizing a resistance breathing device have on participant's well-being when used during a stressful academic period? * To what extent is a diaphragmatic breathing device acceptable for use when utilized during a noted stress-inducing period such as academic examinations?
NCT07525388
This study was conducted to investigate the effects of progressive relaxation exercises, performed with the assistance of a therapeutic clown during the pre-operative period, on fear, anxiety and physiological parameters in children. This randomised controlled trial included children aged 6-10 years undergoing circumcision surgery. The children were randomised into three groups: a progressive relaxation exercise group led by a therapeutic clown, a progressive relaxation group led by a nurse, and a control group. Fear, anxiety and physiological parameters (heart rate, respiratory rate, blood pressure, oxygen saturation) were assessed before and after the procedure.
NCT07521995
This single-blind, randomized controlled trial will employ a two-arm parallel design (exercise group vs. control group) with a 12-week intervention period. Randomization will be implemented using SPSS 25.0 (IBM Corporation, Armonk, NY, USA) to ensure balanced group allocation. All outcome measures will be assessed at baseline and post-intervention.
NCT07525479
This study investigates the effects of self-selected music during warm-up on anaerobic performance in highly trained futsal players during and after Ramadan fasting. Ten male futsal players participated in a randomized, counterbalanced crossover design, completing two experimental conditions: a standardized warm-up with self-selected music and a standardized warm-up without music. Anaerobic performance was assessed using the Running-Based Anaerobic Sprint Test (RAST). Participants performed the tests during Ramadan and again two weeks after Ramadan under both conditions. Key performance outcomes included peak power, mean power, minimum power, and fatigue index. The study aims to determine whether self-selected music can enhance anaerobic performance and whether its effects differ between fasting and non-fasting periods.
NCT07497230
This randomized pilot trial evaluated the feasibility and preliminary effects of using asymmetric high-flow nasal cannula (A-HFNC) during exercise-based pulmonary rehabilitation (PR) in patients with chronic obstructive pulmonary disease (COPD). Thirty patients were randomly assigned to conventional PR or PR supplemented with A-HFNC during aerobic training, completing 12 supervised sessions. The study assessed whether A-HFNC could be safely and acceptably incorporated into PR, and whether it enabled higher training intensity and improved exercise performance. Results showed that the intervention was feasible and safe, with 83% adherence in both groups and no adverse events. Patients in the A-HFNC group trained at significantly higher treadmill inclination and showed a clinically meaningful trend toward greater improvement in maximal exercise tolerance. These findings support the design of a larger definitive trial.
NCT07495540
The aim of our study is to compare and investigate the effects of resistance exercises performed with free weights and those performed using machine systems on muscular parameters and neuromuscular control.
NCT07351097
This study will try to answer the following question: Will adding mini-squat exercises at different angles (30°,45°, and 60°) to leg press exercise influence quadriceps and hamstring strength and H:Q angle in football players?
NCT06995534
De Quervain's disease is a painful tenosynovitis of the abductor pollicis longus and extensor pollicis brevis muscle tendons located in the first dorsal compartment. The primary treatment for De Quervain's disease is conservative; surgical intervention is rarely required. Currently, there is no standardized treatment protocol supported by strong, up-to-date evidence. The aim of this study is to compare the effectiveness of a static hand-wrist resting splint and exercise therapy in the conservative treatment of De Quervain's tenosynovitis. Patients will be evaluated in terms of pain levels, functional/symptom status, hand-finger strength, pressure pain threshold (PPT), tendon cross-sectional area measured by ultrasound, and the presence of effusion findings (semiquantitative; 0-3), and patient satisfaction.
NCT06359210
The goal of this clinical trial is to develop and test an adaptive physical activity (PA) maintenance intervention for cancer survivors, after participating in a community-based exercise oncology program. The main questions it aims to answer are: * Aim 1: Examine the feasibility and acceptability of the intervention among cancer survivors and community partners. The researchers will utilize quantitative surveys, focus groups, and semi-structured interviews to collect information about feasibility, implementation, adaptation, and sustainability. * Aim 2: Examine the effects of the intervention among cancer survivors. The researchers will compare the proportion of participants achieving the exercise guidelines for cancer survivors six-months following completion of the initial exercise program. Participants will participate in a community-based exercise oncology program and then return to three months of free living. Based on the PA measured at the three-month follow-up, participants will be categorized as a "Responder" or "Incomplete Responder", and then randomized to the PA maintenance intervention. Researchers will compare those that are classified as Responders (meeting exercise guidelines for cancer survivors) and Incomplete Responders (not meeting guidelines for cancer survivors) to see what level of intervention is needed to influence sustainable behavior change in this population.
NCT07479875
This study investigated the acute effects of ingesting 400 mg of caffeine administered 30 minutes before Brazilian jiu-jitsu-specific strength endurance tests. Experienced athletes completed two conditions, placebo and caffeine, in a randomized, double-blind, crossover clinical trial. Performance was assessed using the dynamic component of the kimono grip strength test (maximum number of repetitions, MNR) and the isometric component (maximum static lift, MSL), both performed with a gi grip. Rating of perceived exertion, adverse effects, and blinding effectiveness were also evaluated.
NCT07478562
The aim of this study was to investigate the effect of thoracolumbar fascia release on scapular position and upper extremity function in adolescent volleyball players. This randomized controlled trial included a total of 51 adolescent volleyball players (46 girls, 5 boys) aged 12-19 years
NCT07473440
This randomized controlled study investigates the effects of sport-specific training on aerobic adaptation and circulating biomarker responses in trained combat athletes. Exercise induces systemic physiological adaptations through signaling molecules known as exerkines, including myokines and adipokines, which mediate communication between skeletal muscle and other metabolic organs. Forty trained male kickboxers are randomly assigned to either an experimental training group or a control group. The experimental group performs an eight-week sport-specific conditioning program in addition to regular technical training, while the control group maintains their usual training routine. Aerobic capacity is assessed using maximal oxygen uptake (VO₂max). Blood samples are collected before and after the intervention to determine circulating levels of exercise-responsive biomarkers, including myostatin, irisin, apelin, brain-derived neurotrophic factor (BDNF), fibroblast growth factor-21 (FGF21), and adiponectin. The primary objective of the study is to evaluate whether changes in circulating biomarker responses are associated with improvements in aerobic performance. The findings may provide insight into the molecular mechanisms underlying exercise-induced physiological adaptation in combat athletes.