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NCT06219421
The field of artificial intelligence is booming in medicine and in the field of diagnosis. The data can be varied: x-rays, pathology sections, or photographs. It is considered that 30 to 40% of the 7000 rare diseases described to date cause craniofacial dysmorphia. Their detection sometimes requires the trained eye of a geneticist, because certain phenotypic traits are subtle. These diagnostic difficulties and the fact that certain diseases are extremely uncommon lead to considerable diagnostic delays
NCT07311005
In recent years, the desire to achieve a muscular body appearance has been increasingly observed among young men, and this situation may lead to unhealthy behaviors and psychological problems in some individuals. Bigorexia, also referred to as muscle dysmorphia, is considered a significant condition within body image disorders and is characterized by a persistent and unrealistic perception of not being sufficiently muscular. Young men with tendencies toward bigorexia may experience negative body image, feel anxiety related to their physical appearance in social settings, and consequently suffer a decline in their quality of daily life. This phenomenon, which can lead to serious psychological, physical, and social problems, plays an important role in the lives of men. The present study aims to examine the effects of a 12-week digital-based education program provided to young men with bigorexia tendencies on body image, social physique anxiety, and levels of bigorexia. In this research, the effects of a digital-based health education program developed for young men with bigorexia tendencies will be investigated. The study will be conducted using a randomized controlled experimental design, and the impact of the digital health education on participants' body image, social physique anxiety, and bigorexia levels will be evaluated. It is expected that the findings will provide evidence-based data to support the development of healthy lifestyle behaviors among young men, strengthen positive body image, and reduce the risk of bigorexia. Additionally, demonstrating the effectiveness of digital-based educational interventions is anticipated to introduce an innovative approach to public health nursing practice.
NCT07051213
Whole-exome (WES) or whole-genome sequencing (WGS) are recommended as first- or second-tier molecular tests for patients with developmental disorders (DD), but the clinical utility of WGS continues to be debated. This prospective randomized trial involving all Belgian Human Genetics centers compares the standard of care (SoC) - combining WES and microarray or shallow WGS - with WGS for 567 individuals with unexplained DD. The aim of the project is to pave the way towards diagnostic implementation of WGS for rare DD in Belgium. To reach this aim, (1) technical validation is performed at different genetic centres in Belgium, (2) clinical utility of WGS is explored and (3) the health economic impact is mapped.