The Belgian Genome Resource to Resolve Rare Diseases

Inclusion Criteria

• •Intellectual disability/Developmental delay (moderate to profound)
• •Intellectual disability/Developmental delay (mild to moderate) AND family recurrence AND normal parents
• •Intellectual disability/Developmental delay (mild to moderate) AND dysmorphism (≥3 well documented minor signs)
• •One major malformation AND dysmorphism (≥3 well documented minor signs)
• •Multiple major malformations in 2 or more different organ systems.