Clinical Trials in Tennessee

Showing 7881-7900 of 20,239 trials

Lorlatinib in Combination With Chemotherapy in Participants With Metastatic Anaplastic Lymphoma Kinase Positive (ALK+) Non-small Cell Lung Cancer (NSCLC) Who Progressed on Single-agent Lorlatinib

NCT05948462

This clinical trial is an open-label, single arm study evaluating the safest dose of lorlatinib in combination with standard of care chemotherapy in participants with metastatic anaplastic lymphoma kinase positive (ALK+) NSCLC who progressed on prior therapy of lorlatinib alone. The main goals of this study are to: * Evaluate the safety and tolerability of lorlatinib in combination with standard of care chemotherapy. * Evaluate how well the combination of lorlatinib and standard of care chemotherapy works to treat metastatic anaplastic lymphoma kinase positive (ALK+) NSCLC. * Evaluate the pharmacokinetics (PK) of lorlatinib when given in combination with standard of care chemotherapy.

Lung CancerNon-small Cell Lung Cancer

SCRI Development Innovations, LLCStarted Nov 2023

Denver, Colorado, United States • Asheville, North Carolina, United States • Nashville, Tennessee, United States +2 more locations

WITHDRAWN29 miles

Single Center, Prospective, Randomized, Controlled, Non-significant Risk

NCT03286166

A randomized controlled trial to evaluate the efficiency of serum tears made with Genius PRP for improving signs and symptoms in Dry Eye Disease (DED). Single center, Prospective, Randomized, Controlled, Non-significant risk

Dry Eye

Toyos ClinicStarted Dec 2021

Nashville, Tennessee, United States

COMPLETEDPhase 2154 miles

Micronized dHACM vs. Saline in the Treatment of Osteoarthritis of the Knee

NCT03485157

The purpose of this study is to determine the safety and effectiveness of micronized dehydrated human amnion chorion membrane as compared to the 0.9% Sodium Chloride Injection, USP placebo control for the treatment of knee osteoarthritis

Knee Osteoarthritis

MiMedx Group, Inc.447 participantsStarted Mar 2018

Birmingham, Alabama, United States • Tempe, Arizona, United States • La Mesa, California, United States +14 more locations

Lorlatinib in Combination With Chemotherapy in Participants With Metastatic Anaplastic Lymphoma Kinase Positive (ALK+) Non-small Cell Lung Cancer (NSCLC) Who Progressed on Single-agent Lorlatinib

Single Center, Prospective, Randomized, Controlled, Non-significant Risk

Micronized dHACM vs. Saline in the Treatment of Osteoarthritis of the Knee

Find Trials by Condition in Tennessee

Exploratory PK and Imaging Study of PSMA-Targeted Trillium Compounds and PTI-122 in Metastatic Prostate Cancer

A Study of Efficacy and Safety of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis

JUNIPER: A Phase 2 Study to Evaluate the Safety, Biological Activity, and PK of ND-L02-s0201 in Subjects With IPF

iCanCope With Sickle Cell Pain

Study of Narazaciclib (ON 123300) Plus Letrozole in Endometrial Cancer and Other Gynecologic Malignancies

A Clinical Trial to Confirm Safety & Effectiveness of the SYNERGY 4.50 mm and 5.00 mm Stent for Treatment of Atherosclerotic Lesion(s)

A Study to Evaluate the Efficacy and Safety of Maralixibat in Subjects With Progressive Familial Intrahepatic Cholestasis (MARCH-PFIC)

Aggressive Smoldering Curative Approach Evaluating Novel Therapies and Transplant

Open Label Study of R788 in the Treatment of Persistent/Chronic Immune Thrombocytopenic Purpura (ITP)

Phase II Trial of Combination Immunotherapy With NeuVax and Trastuzumab in High-risk HER2+ Breast Cancer Patients

Double-blind Study to Evaluate the Safety and Efficacy of Antroquinonol in Mild-Moderate COVID-19 Hospitalized Patients

A Study Evaluating the Safety, Tolerability, and Effect on Microvascular Obstruction of Intravenous Temanogrel in Adult Participants Undergoing Percutaneous Coronary Intervention

Dexmedetomidine in the Treatment of Agitation Associated With Dementia (TRANQUILITY III)

A Study of PRT2527 in Participants With Advanced Solid Tumors

Association of Endothelial Function and Clinical Outcomes in Subjects Admitted to Chest Pain Unit

Study to Evaluate the Safety and Activity (Including Distribution) of 177Lu-3BP-227 in Subjects With Solid Tumours Expressing Neurotensin Receptor Type 1.

Eltrombopag Combined With Cyclosporine as First Line Therapy in Patients With Severe Acquired Aplastic Anemia