Dexmedetomidine in the Treatment of Agitation Associated With Dementia (TRANQUILITY III)

Exclusion Criteria

• •1. Subjects with dementia or other memory impairment not due to probable AD.
• •2. Clinical diagnosis of probable AD should not be applied when there is evidence of a cerebrovascular incident temporally related to the worsening of cognitive function.
• •3. Subjects with agitation caused by acute intoxication.
• •4. Subjects with significant risk of suicide or homicide per the investigator's assessment.
• •5. Subjects who are medically unstable or in recovery. Note: Subjects with a remote (\>5 years) history of stroke may be included, regardless of size/location.
• •6. History of clinically significant syncope or syncopal attacks, orthostatic hypotension within the past 2 years, current evidence of hypovolemia, orthostatic hypotension, bradycardia.
• •7. Subjects with laboratory or ECG abnormalities.
• •8. Subjects who have received an investigational drug within 30 days prior to Screening.
• •9. Subjects who are currently suffering from substance abuse.
• •10. Subjects with a potential cause for delirium (relatively recent onset agitation and dementia)