Clinical Trials in Tennessee

Showing 5421-5440 of 20,239 trials

First-in-Human Study of RLY-5836 in Advanced Breast Cancer and Other Solid Tumors

NCT05759949

This is a Phase 1, first-in-human, open-label study designed to evaluate the maximum tolerated dose (MTD), recommended phase 2 dose (RP2D), safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of RLY-5836 in advanced solid tumors in participants harboring a PIK3CA mutation in blood and/or tumor per local assessment. The study consists of 2 parts, a dose escalation (Part 1) and a dose expansion (Part 2).

PIK3CA MutationSolid Tumor, AdultHER2-negative Breast Cancer+5 more

Relay Therapeutics, Inc.41 participantsStarted Mar 2023

Orlando, Florida, United States • Indianapolis, Indiana, United States • Boston, Massachusetts, United States +4 more locations

COMPLETEDNA29 miles

Early Integrated Telehealth Versus In-Person Palliative Care for Patients With Lung Cancer

NCT03375489

This research study is evaluating ways to provide palliative care to patients who have recently been diagnosed with lung cancer and their families.

Lung Cancer

Massachusetts General Hospital1,798 participantsStarted Jun 2018

Birmingham, Alabama, United States • Los Angeles, California, United States • San Francisco, California, United States +20 more locations

First-in-Human Study of RLY-5836 in Advanced Breast Cancer and Other Solid Tumors

Early Integrated Telehealth Versus In-Person Palliative Care for Patients With Lung Cancer

Find Trials by Condition in Tennessee

VZV in the Enteric Nervous System: Pathogenesis and Consequences

A Study of a Patient-Specific Neoantigen Vaccine in Combination With Immune Checkpoint Blockade for Patients With Metastatic Colorectal Cancer

VAY736 in Combination With Ibrutinib in Patients With CLL on Ibrutinib

Efficacy, Safety and Tolerability of Balcinrenone/Dapagliflozin Compared to Dapagliflozin in Adults With Chronic Kidney Disease

Study of TH-302 or Placebo in Combination With Pemetrexed in Patients With Non-squamous Non-small Cell Lung Cancer

Study of Safety, Efficacy and Tolerability of Secukinumab Versus Placebo, in Combination With SoC Therapy, in Patients With Active Lupus Nephritis

Integrated e-Health (Electronic Health) for HIV and Substance Use Disorders in Justice Involved Women

Safety, Tolerability and Pharmacokinetics Study of KPG-818 in Hematological Malignancies Subjects

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

Dose-Ranging Study of ST-920, an AAV2/6 Human Alpha Galactosidase A Gene Therapy in Subjects With Fabry Disease (STAAR)

Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response

A Trial Evaluating the Safety and Effects of an RNA Vaccine ARCT-021 in Healthy Adults

Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Liver Transplant Recipients With Additional 12-month Follow-up and Long-term Extension

Natural Versus Programmed Frozen Embryo Transfer (NatPro)

A Study of IMR-687 in Adult Participants With Sickle Cell Anemia (Homozygous HbSS or Sickle-β0 Thalassemia)

7-week Study With CT-155 in People With Schizophrenia

Cognition and Imaging With Tigertriever

A Phase 1/2 Study to Evaluate the Safety, Tolerability and PK of JIN-A02 in Patients With EGFR Mutant Advanced NSCLC