First-in-Human Study of RLY-5836 in Advanced Breast Cancer and Other Solid Tumors

Inclusion Criteria

• •Patient has ECOG performance status of 0-1
• •One or more documented primary oncogenic PIK3CA mutation(s) in blood and/or tumor per local assessment
• •Disease that is refractory to standard therapy, intolerant to standard therapy, or participant has declined standard therapy.
• •A histologically or cytologically confirmed diagnosis of unresectable or metastatic solid tumor
• •Males, postmenopausal females, or pre-/perimenopausal females previously treated with gonadotropin-releasing GnRH agonist at least 4 weeks prior to start of study drug with histologically or cytologically confirmed diagnosis of HR+, HER2- unresectable or metastatic breast cancer that is not amenable to curative therapy.
• •Had previous treatment for advanced or metastatic breast cancer with antiestrogen therapy including, but not limited to, selective estrogen receptor degraders (e.g., fulvestrant), selective estrogen receptor modulators (e.g., tamoxifen), and aromatase inhibitors (AI) (letrozole, anastrozole, exemestane)
• •Part 1: Prior PI3Kα inhibitor treatment is allowed if taken for \< 14 days and not discontinued due to disease progression, hypersensitivity, or ≥ Grade 3 TEAEs.