Clinical Trials in Seattle

Showing 5281-5300 of 9,312 trials

Anti-CD20 Radioimmunotherapy Before Chemotherapy and Stem Cell Transplant in Treating Patients With High-Risk B-Cell Malignancies

NCT02483000

This phase I/II trial studies the side effects and best dose of anti-cluster of differentiation (CD)20 radioimmunotherapy (RIT), and to see how well it works when given before chemotherapy and stem cell transplant in treating patients with B-cell malignancies that have not responded to treatment or have come back after responding to treatment. CD20 is a protein found on the cells of a type of cancer cell called B-cells. Anti-CD20 RIT attaches radioactive material to a drug that is designed to target CD20, which brings radioactive material to the cancer cells to kill the cells. This may kill more tumor cells while causing fewer side effects to healthy tissue. Adding anti-CD20 to standard chemotherapy and stem cell transplant may be more effective in treating patients with B-cell malignancies.

Burkitt LymphomaCD20-Positive Neoplastic Cells PresentDiffuse Large B-Cell Lymphoma+4 more

Fred Hutchinson Cancer Center3 participantsStarted Feb 2017

Seattle, Washington, United States

COMPLETEDPhase 2< 1 mile

Myelodysplastic Syndromes (MDS) Event Free Survival With Iron Chelation Therapy Study

NCT00940602

This was a randomized, double-blind trial to evaluate deferasirox vs placebo in patients with myelodysplastic syndromes (low/int-1 risk) and transfusional iron overload .The trial was conducted in 17 countries, started in 2010 and ended in 2018.

Myelodysplastic Syndromes

Novartis Pharmaceuticals225 participantsStarted Mar 2010

Anaheim, California, United States • Greenwood Village, Colorado, United States • Shreveport, Louisiana, United States +68 more locations

Anti-CD20 Radioimmunotherapy Before Chemotherapy and Stem Cell Transplant in Treating Patients With High-Risk B-Cell Malignancies

Myelodysplastic Syndromes (MDS) Event Free Survival With Iron Chelation Therapy Study

Find Trials by Condition in Seattle

Induction Chemotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck

Study to Evaluate Efficacy, Safety, Tolerability, and Pharmacodynamics of Entospletinib in Adults With Relapsed or Refractory Hematologic Malignancies

A Smartphone Intervention for Relational and Mental Well Being

PRISM: Efficacy and Safety of Cobomarsen (MRG-106) in Subjects With Mycosis Fungoides Who Have Completed the SOLAR Study

TRANSFIX Zenith® Transection Clinical Study

Dose-finding Study of GLPG0634 as add-on to Methotrexate in Active Rheumatoid Arthritis Participants (DARWIN1)

Spinal Cord Stimulation With Precision® System Versus Reoperation for Failed Back Surgery Syndrome

Investigating Superion™ In Spinal Stenosis

An Exploratory Study of Caregiver Burden Among Family Caregivers of Patients With Cancer

Study of Nasal Insulin to Fight Forgetfulness - Long-acting Insulin Detemir - 120 Days (SL120)

Canadian Humira Post Marketing Observational Epidemiological Study Assessing Effectiveness in Psoriatic Arthritis

Study of Ataluren for Previously Treated Participants With Nonsense Mutation Duchenne/Becker Muscular Dystrophy (nmDBMD) in Europe, Israel, Australia, and Canada

An Open-label Extension Study To Evaluate Safety Of PF-06252616 In Boys With Duchenne Muscular Dystrophy

A Study of Imatinib Versus Nilotinib in Adult Patients With Newly Diagnosed Philadelphia Chromosome Positive (Ph+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP)

Avelumab in Third-Line Gastric Cancer (JAVELIN Gastric 300)

A Survival Study for Women With Advanced Lung Cancer Who Have Not Previously Received Chemotherapy.

Safety and Tolerability Study of Flexible Dosing of Brexpiprazole in the Treatment of Subjects With Agitation Associated With Dementia of the Alzheimer's Type

Efficacy and Safety of IgPro10 in Adults With Systemic Sclerosis (SSc)