Clinical Trials in San Francisco

Showing 5901-5920 of 12,991 trials

Dose Escalation of RMC-4630 Monotherapy in Relapsed/Refractory Solid Tumors

NCT03634982

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of escalating doses of RMC-4630 monotherapy in adult participants with relapsed/refractory solid tumors and to identify the recommended Phase 2 dose (RP2D).

Solid Tumors

Revolution Medicines, Inc.133 participantsStarted Sep 2018

Scottsdale, Arizona, United States • Duarte, California, United States • Orange, California, United States +9 more locations

TERMINATED< 1 mile

Novel Quantitative MRI for Axial Spondyloarthritis

NCT03778515

This proposal aims to develop novel MR imaging and image processing techniques that will provide reliable and fully quantitative evaluation of inflammation, chronic structural changes and vascularity in patients with Ankylosing Spondylitis (AS). The quantitative evaluation will be more objective and reproducible, more sensitive to subtle changes, and less time consuming, as compared to the current semi-quantitative evaluation. It will allow radiologists and rheumatologists to evaluate the inflammation and structural changes more reliably to improve early diagnosis and treatment response evaluation. The developed quantification tools can be disseminated to other research and clinical sites for retrospective and prospective data analysis, and used as outcome measures for future multi-center trials. The evaluation of vascularity will enhance Investigators understanding of disease pathophysiology and serve as a novel marker to improve investigators capability of evaluating and predicting treatment response in AS. The successful implementation will greatly assist clinicians to optimize individualized therapeutic strategies and ultimately improve patient care for AS.

Spondylitis, Ankylosing

The Cleveland Clinic1 participantsStarted Jan 2020

San Francisco, California, United States

Dose Escalation of RMC-4630 Monotherapy in Relapsed/Refractory Solid Tumors

Novel Quantitative MRI for Axial Spondyloarthritis

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Effect of Remote Physiologic Monitoring (RPM) on Outcomes in COPD Patients

Subject Satisfaction With AbobutulinumtoxinA Treatment

Sapanisertib or Pazopanib Hydrochloride in Treating Patients With Locally Advanced or Metastatic Sarcoma

Tau Imaging With JNJ067

Evaluation of EverLift in the Performance of Polypectomy for Polyps 4-9mm

Long-term Neurocognitive Sequelae of Subclinical Microembolization During Carotid Interventions

Computer-assisted Oxygen Therapy Weaning in Critically Ill Children

Serratus Anterior Plane Block for Improving Pain and Respiratory Function in Patients With Multiple Rib Fractures

Seasonal Influenza HA DNA With Trivalent Inactivated Vaccine (TIV) Administered ID or IM in Healthy Adults 18-70 Years

Phase 2 Study on Effects of Obeticholic Acid (OCA) on Lipoprotein Metabolism in Participants With Primary Biliary Cirrhosis

A Study of Mirikizumab (LY3074828) in Participants With Active Crohn's Disease

Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Miricorilant in Participants With Presumed Nonalcoholic Steatohepatitis (NASH)

Clobetasol Propionate Spray Versus Vehicle Spray for the Management of Moderate to Severe Plaque Psoriasis of the Scalp

Mentors Offering Maternal Support (M-O-M-S™): A Prenatal Program for Decreasing Maternal Anxiety and Depression

Long-term Follow-Up Study Following Treatment With Fate Therapeutics' Engineered Cellular Immunotherapy

Safety & Effectiveness of Clobex Spray, Followed by Calcitriol Ointment in Management of Plaque Psoriasis

A Prospective Study of Early Mechanical Stabilization and Bleeding in Disruption of the Pelvic Ring

Post Market Clinical Protocol - Xtremity Polymer Prosthetic Socket System