Clinical Trials in San Francisco

Showing 3001-3020 of 11,161 trials

A Standard of Care Study of Patients With Major Depressive Disorder Who Have Had an Inadequate Response to a Selective Serotonin Reuptake/Serotonin-Norepinephrine Reuptake Inhibitor Antidepressant

NCT05109195

The purpose of this study is to assess the safety (adverse events, serious adverse events, deaths, suicidality) of participants with major depressive disorder (MDD) treated according to the standard of care (SOC).

Depressive Disorder, Major

Janssen Research & Development, LLC7 participantsStarted Oct 2021

San Francisco, California, United States • Boston, Massachusetts, United States • Pittsburgh, Pennsylvania, United States +1 more locations

COMPLETEDPhase 4< 1 mile

A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant Depression

NCT04599855

The purpose of this study is to evaluate the efficacy of each individual dose of esketamine nasal spray, 56 milligram (mg) and 84 mg, compared with placebo nasal spray in improving depressive symptoms in participants with treatment resistant depression (TRD), as assessed by the change from baseline in the Montgomery-Asberg Depression Rating Scale (MADRS) total score from Day 1 (prerandomization) to the end of the 4 week double-blind treatment phase (Day 28).

Depressive Disorder, Treatment-Resistant

Janssen Research & Development, LLC477 participantsStarted Nov 2020

Birmingham, Alabama, United States • Huntsville, Alabama, United States • Little Rock, Arkansas, United States +51 more locations

A Standard of Care Study of Patients With Major Depressive Disorder Who Have Had an Inadequate Response to a Selective Serotonin Reuptake/Serotonin-Norepinephrine Reuptake Inhibitor Antidepressant

A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant Depression

Find Trials by Condition in San Francisco

Summertime: Kids in Motion

A Multiple-dose Study of ASP8374, an Immune Checkpoint Inhibitor, as a Single Agent and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

Efficacy Study of Nivolumab Compared to Ipilimumab in Prevention of Recurrence of Melanoma After Complete Resection of Stage IIIb/c or Stage IV Melanoma

Lemborexant in Delayed Sleep Phase Syndrome

Mindfulness Approach for Reducing Anxiety and Gloom in Ocular Inflammatory Diseases

Long-term Follow-up Study With Darvadstrocel in the Treatment of Complex Perianal Fistula

A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant and Long-term Safety Extension Treatment With Seltorexant

Safety and Efficacy of GS-100 Gene Therapy in Patients With NGLY1 Deficiency

A Study of Seltorexant in Participants With Probable Alzheimer's Disease

A Study of JNJ-73763989 + Nucleos(t)Ide Analog in Participants Co-Infected With Hepatitis B and Hepatitis D Virus

High Resolution Wavefront-guided vs. Wavefront Optimized LASIK

BEAD-T1D: Building the Evidence to Address Disengagement in Type 1 Diabetes

DALY II USA/ MB-CART2019.1 for DLBCL

A Study to Investigate the Efficacy and Safety of Canagliflozin in Children and Adolescents (>=10 to <18 Years) With Type 2 Diabetes Mellitus

Burn Validation Study

The Celljuvant Study: A Phase 3 Immunogenicity and Safety Study of aQIVc Vaccine in Adults Aged 50 Years and Older

Open-Label Extension: Tolerability and Effects of ALK-001 on Stargardt Disease (TEASE)

HiLo: Pragmatic Trial of Higher vs Lower Serum Phosphate Targets in Patients Undergoing Hemodialysis