Clinical Trials in Pittsburgh

Showing 16841-16860 of 21,047 trials

A Study Evaluating INIPARIB in Combination With Chemotherapy to Treat Triple Negative Breast Cancer Brain Metastasis

NCT01173497

The purpose of the study is to investigate the response rate for triple negative breast cancer patients with brain metastasis when INIPARIB is used in combination with irinotecan. Based on data generated by BiPar/Sanofi, it is concluded that iniparib does not possess characteristics typical of the PARP inhibitor class. The exact mechanism has not yet been fully elucidated, however based on experiments on tumor cells performed in the laboratory, iniparib is a novel investigational anti-cancer agent that induces gamma-H2AX (a marker of DNA damage) in tumor cell lines, induces cell cycle arrest in the G2/M phase in tumor cell lines, and potentiates the cell cycle effects of DNA damaging modalities in tumor cell lines. Investigations into potential targets of iniparib and its metabolites are ongoing.

Estrogen Receptor Negative (ER-Negative) Breast CancerProgesterone Receptor Negative (PR-Negative) Breast CancerHuman Epidermal Growth Factor Receptor 2 Negative (HER2-Negative) Breast Cancer+1 more

Sanofi44 participantsStarted Jul 2010

Birmingham, Alabama, United States • San Francisco, California, United States • Washington D.C., District of Columbia, United States +10 more locations

TERMINATEDNA< 1 mile

Randomized Fistula Study

NCT00808561

The primary objective of this study is to compare two treatment strategies for establishing dialysis access in patients with unsuitable forearm veins for the standard forearm primary radio-cephalic arteriovenous fistula also known as the Brescia-Cimino fistula.

Renal Failure

University of Pittsburgh6 participantsStarted Dec 2008

Pittsburgh, Pennsylvania, United States

A Study Evaluating INIPARIB in Combination With Chemotherapy to Treat Triple Negative Breast Cancer Brain Metastasis

Randomized Fistula Study

Find Trials by Condition in Pittsburgh

Efficacy, Safety And Tolerability Study Of RN6G In Subjects With Geographic Atrophy Secondary to Age-related Macular Degeneration

A Study of Investigational SAR245409 in Patients With Certain Lymphoma or Leukemia

Trial of Gemcitabine/Carboplatin With or Without Iniparib (SAR240550) (a PARP1 Inhibitor) in Subjects With Previously Untreated Stage IV Squamous Non-Small-Cell Lung Cancer (NSCLC)

A Long-Term Safety and Efficacy Study of Eszopiclone in Elderly With Primary Chronic Insomnia

Open Label Extension of Prior TERMS Study to Treat Relapsing Forms of Multiple Sclerosis

Evaluation of the Efficacy and Safety of E2007 (Perampanel) Given as Adjunctive Therapy in Subjects With Refractory Partial Seizures

Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers

Safety and Efficacy Study of Ramelteon (TAK-375) Tablets for Sublingual Administration (SL) in Adults With Bipolar 1 Disorder

Ocriplasmin for Treatment for Symptomatic Vitreomacular Adhesion Including Macular Hole

Post-Approval Study of MelaFind

Study of Intravenous NRX-1074 in Patients With Major Depressive Disorder

Bosutinib For Autosomal Dominant Polycystic Kidney Disease

An Observational Study on Long-Term Persistence of Resistant Mutations And Durability of Sustained Virological Response in Patients With Chronic Hepatitis C Treated With Direct Acting Antiviral (DAA)- Containing Regimens

Efficacy and Safety of GLYX-13 in Subjects With Inadequate/Partial Response to Antidepressants

Atacicept Phase 2/3 in Generalized Systemic Lupus Erythematosus (APRIL-SLE)

APT001 Plasma/NO Generator to Treat Diabetic Foot Ulcer in Adults

Elder Surgery - Functional Recovery Following Beta Blockade

Comparison of AZD6244 in Combination With Dacarbazine Versus (vs) Dacarbazine Alone in BRAF Mutation Positive Melanoma Patients