Clinical Trials in Pittsburgh

Showing 16821-16840 of 21,047 trials

Study of Acute Peripheral Vascular Effects, Safety and Tolerability in Subjects With Raynaud's Phenomenon Secondary to Systemic Sclerosis

NCT02228850

The purpose of this study is to evaluate pharmacodynamics (PD) in adult subjects with a diagnosis of Raynaud's Phenomenon secondary to Systemic Sclerosis (SSc).

Raynaud's Phenomenon Secondary to Systemic Sclerosis

NexMed (U.S.A.), Inc. (subsidiary of Apricus Biosciences, Inc.)35 participantsStarted Nov 2014

Encinitas, California, United States • Ann Arbor, Michigan, United States • Cleveland, Ohio, United States +1 more locations

COMPLETEDNA< 1 mile

Pathogenesis of Stress-Induced Cardiomyopathy by I-123 MIBG

NCT01432626

Objective: The objective of this pilot study is to characterize the cardiac uptake patterns of I-123 mIBG in stress-induced (Takotsubo's) cardiomyopathy. Hypothesis: Perturbations in sympathetic innervation are the underlying pathogenesis of stress induced cardiomyopathy and will result in abnormalities in I-123 mIBG cardiac imaging. Thus, planar and SPECT I-123 MIBG imaging will provide insight into the pathogenesis of stress-induced cardiomyopathy, and may lead to the development of more specific diagnostic criteria. Study design: This proposal is for a prospective pilot study to characterize perturbations in cardiac sympathetic innervation in patients with stress induced cardiomyopathy by performing planar and SPECT I-123 MIBG imaging during the acute presentation and after recovery of LV function.

Stress Induced Cardiomyopathy

University of Pittsburgh10 participantsStarted Sep 2011

Pittsburgh, Pennsylvania, United States

Study of Acute Peripheral Vascular Effects, Safety and Tolerability in Subjects With Raynaud's Phenomenon Secondary to Systemic Sclerosis

Pathogenesis of Stress-Induced Cardiomyopathy by I-123 MIBG

Find Trials by Condition in Pittsburgh

Evaluation of Weekly Idrabiotaparinux Sodium Versus Oral Adjusted-dose Warfarin to Prevent Stroke and Systemic Thromboembolic Events in Patients With Atrial Fibrillation

Study Intended to Evaluate the Safety and Effectiveness of a Johnson & Johnson Vision Care Inc, (JJVCI) Contact Lens for Use on an Extended-wear Basis for up to 7 Days (6 Nights).

Chemotherapy With or Without Strontium-89 in Treating Patients With Prostate Cancer

The Efficacy and Safety of Atacicept in Combination With Mycophenolate Mofetil Used to Treat Lupus Nephritis

Retrospective Multicenter Study to Determine 4-Year Clinical Outcomes in Subjects Previously Enrolled in the CTOT-05 Study

Study of Intravenous NRX-1074 in Patients With Major Depressive Disorder

Safety and Efficacy of EVT 101 in Treatment-Resistant Depression

Efficacy and Safety of GLYX-13 in Subjects With Inadequate/Partial Response to Antidepressants

Randomized Trial of Suicide Gene Therapy and Prostate Cancer

A Study Evaluating the Safety, Tolerability, and Pharmacokinetics of GDC-0973 in Combination With GDC-0068 When Administered in Participants With Locally Advanced or Metastatic Solid Tumors

Cognitive Function and Fatigue in Colorectal Cancer (CRC) Patients After Chemotherapy

Clinical Study Assessing Idrabiotaparinux Sodium Injections Once-weekly in Pulmonary Embolism Therapeutic Approach

Bioequipotency Study of Idrabiotaparinux and Idraparinux in Patients With Deep Venous Thrombosis of the Lower Limbs

Long-term, Safety and Tolerability Study of AFQ056 in Adolescent Patients With Fragile X Syndrome (Open-label)

Performance of the ePrime System for Cellulite

A Pharmacokinetic Study of Single-Dose Intravenous Ustekinumab Delivered in 2 Different Liquid in Vial Formulations

Clinical Outcomes and Safety: A Registry Study of Ilaris (Canakinumab) Patients

Bioequivalence Study of IG-001 Versus Nab-paclitaxel in Metastatic or Locally Recurrent Breast Cancer