Clinical Trials in Pittsburgh

Showing 2661-2680 of 18,076 trials

Treatment, Emotion, and Neuromodulation of Depression (TREND) Study

NCT05436379

The investigators will administer theta burst stimulation (TBS) in efforts to observe a decrease in severity of reported depression symptoms. A subset of participants will receive positive affect training during this intervention.

Depression

Erika Forbes21 participantsStarted Jun 2022

Pittsburgh, Pennsylvania, United States

Active Not RecruitingPhase 2< 1 mile

A Phase 2b, Dose-range Finding Study of the Efficacy and Safety of Multiple Doses of Aleniglipron (GSBR-1290) in Participants Living With Obesity or Overweight With at Least One Weight-related Comorbidity

NCT06693843

This study is a randomized, double-blind, placebo-controlled, dose-range finding study of the efficacy, safety, tolerability, PK, and PD of multiple doses of aleniglipron in participants living with overweight or obesity with at least one weight-related comorbidity. Participants will be randomized to aleniglipron or placebo in a ratio of 3:1 within each Cohort receiving multiple-ascending, QD doses of aleniglipron or placebo in titration steps of 4 weeks duration for a total of 36 weeks of treatment. At the end of the study (after completing 36 weeks of treatment), participants will be offered to continue with an open-label extension (OLE) where they will receive aleniglipron for an additional 36 weeks.

Obesity, Overweight, or Chronic Weight Management

Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics220 participantsStarted Oct 2024

Phoenix, Arizona, United States • Anaheim, California, United States • Los Angeles, California, United States +36 more locations

Treatment, Emotion, and Neuromodulation of Depression (TREND) Study

A Phase 2b, Dose-range Finding Study of the Efficacy and Safety of Multiple Doses of Aleniglipron (GSBR-1290) in Participants Living With Obesity or Overweight With at Least One Weight-related Comorbidity

Find Trials by Condition in Pittsburgh

A Research Study Comparing How Well Different Doses of the Medicine NNC0487-0111 Lower Blood Sugar in People With Type 2 Diabetes

Deep Phenotyping of the Renal Allograft to Prognosticate Clinical Outcomes

Prevention of Colorectal Cancer Through Multiomics Blood Testing

Observational Study Protocol: LIVER-R

Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer

Observational Basket Trial to Collect Tissue to Develop and Train a Live Tumor Diagnostic Platform

A Phase 2b Study to Evaluate Rezpegaldesleukin (Rezpeg) in the Treatment of Severe to Very Severe Alopecia Areata in Adult Patients (Rezolve AA)

Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis (MK-7240-011)

Research Study Investigating How Well NDec Works in People With Sickle Cell Disease

Acute Video-oculography for Vertigo in Emergency Rooms for Rapid Triage (AVERT)

Study of Denikitug (GS-1811) Given Alone or With Zimberelimab in Adults With Advanced Solid Tumors

Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery

SPI-1005 for the Treatment of Meniere's Disease (Open Label)

Acute Hip Fracture Study in Patients 65 Years or Greater

A Study to Evaluate the Safety, Pharmacokinetics, and Occurrence of Anti-Drug Antibodies Following Annual Doses of CD388

Preliminary Study of Brain Effects of Palynziq-Related Changes in Phenylalanine in Individuals With PKU

Community Collaboration to Advance Racial/Ethnic Equity in CRC Screening

A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO)