Clinical Trials in Philadelphia

Showing 12321-12340 of 20,904 trials

Regorafenib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor

NCT01068769

The purpose of this research study is to determine the safety and activity of regorafenib in participants with advanced gastrointestinal stromal tumor (GIST) if the standard approved therapies, imatinib and sunitinib, have failed to control the disease. Regorafenib is a drug that blocks abnormally active signaling enzymes called "tyrosine kinases" which are important to the growth of GIST. This "tyrosine kinase inhibition" is similar to the way that both imatinib and sunitinib work; however, regorafenib blocks certain additional signaling pathways that are not blocked by imatinib or sunitinib. Regorafenib has been not been tested in GIST participants before this research study.

Gastrointestinal Stromal Tumor

Suzanne George, MD34 participantsStarted Feb 2010

Boston, Massachusetts, United States • Boston, Massachusetts, United States • Portland, Oregon, United States +1 more locations

COMPLETEDPhase 2< 1 mile

Follow up 18F-AV-1451 Scan in Confirmatory Cohort Subjects From Study 18F-AV-1451-A05

NCT02795780

This study will evaluate longitudinal change of tau deposition as measured by flortaucipir F 18 uptake over time.

Alzheimer's Disease

Avid Radiopharmaceuticals79 participantsStarted Aug 2016

Phoenix, Arizona, United States • Scottsdale, Arizona, United States • Scottsdale, Arizona, United States +19 more locations

Regorafenib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor

Follow up 18F-AV-1451 Scan in Confirmatory Cohort Subjects From Study 18F-AV-1451-A05

Find Trials by Condition in Philadelphia

A Study of Pegylated Interferon Alfa-2A in Combination With Lamivudine or Entecavir Compared With Untreated Control Group in Children With Hepatitis B Envelope Antigen (HBeAg)-Positive Chronic Hepatitis B (CHB) in the Immune-Tolerant Phase

Telbivudine in Adults Previously Treated in Idenix-Sponsored Telbivudine Studies

Glembatumumab Vedotin in Treating Patients With Metastatic or Locally Recurrent Uveal Melanoma

Evaluation of Splinting in Tetraplegia

Safety and Efficacy Study of Spinal Tethering

Codex: Study of Inodiftagene Vixteplasmid (BC-819) in Unresponsive NMIBC

Ostomy Telehealth For Cancer Survivors

LEO 90100 Twice Weekly Maintenance Regimen for Psoriasis Vulgaris

Safety and Efficacy of IDP-118 in the Treatment of Plaque Psoriasis

A Safety and Efficacy Study of Farletuzumab in Participants With Adenocarcinoma of the Lung

Dose-Escalation Study of Intraperitoneal (IP) Cisplatin, IV/IP Paclitaxel, IV Bevacizumab, and Oral Olaparib for Newly Diagnosed Ovarian, Primary Peritoneal, and Fallopian Tube Cancer

Acthar Gel for Active Systemic Lupus Erythematosus (SLE)

To Study Generic Calcipotriene and Betamethasone Dipropionate Topical Foam, 0.005%/0.064%, in the Treatment of Psoriasis Vulgaris (Plaque Psoriasis).

Safety and Efficacy of BAY94-9027 in Previously Treated Male Children With Haemophilia A

Study Evaluating Oral MOA-728 For The Treatment Of OIBD In Subjects With Chronic Non-Malignant Pain

Study of Efficacy and Safety of Brodalumab in Subjects With Psoriatic Arthritis

Dose Ranging Study to Evaluate Immunogenicity and Safety of Adjuvanted or Non-adjuvanted Cell Culture-derived H5N1 Influenza Vaccine in Young Adults (18-40 Years Old)

Study of Endorectal Cooling During RARP to Minimize Trauma and Promote Earlier Return to Continence