Clinical Trials in Philadelphia

Showing 12021-12040 of 20,904 trials

Study of AMN107 With Imatinib in Gastrointestinal Stromal Tumors (GIST)

NCT00135005

This study is an open-label, multicenter, Phase I dose-escalation study of the combination of AMN107 and imatinib (STI571) in patients with imatinib-resistant GIST. This study is designed to determine the Phase II dose of AMN107 and imatinib when administered together in patients with imatinib-resistant GIST, and to characterize the safety, tolerability and pharmacokinetic (PK) profile of this combination.

Gastrointestinal Stromal Tumors

Novartis Pharmaceuticals59 participantsStarted Aug 2005

Boston, Massachusetts, United States • Philadelphia, Pennsylvania, United States • Lyon, France +2 more locations

COMPLETEDPhase 3< 1 mile

Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location

NCT02152696

This is a randomized controlled trial to compare three currently available management strategies for women with a persisting pregnancy of unknown location (PPUL), which makes them at-risk for ectopic pregnancy. We will recruit hemodynamically stable women with a confirmed PPUL to be randomized to one of three strategies: 1) Uterine evacuation followed by methotrexate (MTX) for some (those that have evidence of a non visualized ectopic pregnancy) 2) Empiric treatment with MTX for all 3) Expectant management. Randomization will be 1:1:1 into these three arms. After randomization, they will be followed and treated clinically as is indicated by the progression of their condition. Primary outcome measures: uneventful decline of hCG to 5 IU/mL.

Persistent Pregnancy of Unknown LocationEctopic Pregnancy

Yale University255 participantsStarted Jul 2014

San Francisco, California, United States • Denver, Colorado, United States • New Haven, Connecticut, United States +14 more locations

Study of AMN107 With Imatinib in Gastrointestinal Stromal Tumors (GIST)

Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location

Find Trials by Condition in Philadelphia

PET/CT in Psoriatic Arthritis

A Phase 2 Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of PF-06252616 in Duchenne Muscular Dystrophy

Hand Incision Study

Levofloxacin in Preventing Infection in Young Patients With Acute Leukemia Receiving Chemotherapy or Undergoing Stem Cell Transplantation

Zinc & Bone Health in Thalassemia: The Think Zinc Study

Id-KLH Vaccine + T Cells in Subjects With Myeloma Undergoing Transplant

Validation of Point of Care Liver Function Tests

Efficacy, Safety, and Pharmacokinetics of Brachial Plexus Block With EXPAREL in Shoulder Surgery

Combination Chemotherapy With or Without Chemoembolization in Treating Patients With Colorectal Cancer Metastatic to the Liver (6655)

Combination Immunotherapy With Herceptin and the HER2 Vaccine NeuVax

Follow-up of the PEPITES Study to Evaluate Long-term Efficacy and Safety of Viaskin Peanut in Children

Study of Epratuzumab Versus Placebo in Subjects With Moderate to Severe General Systemic Lupus Erythematosus (SLE)

Evaluation of Deep Transcranial Magnetic Stimulation (DTMS) With the H-ADD Coil as an Aid to Smoking Cessation.

Fluid Responsiveness Evaluation in Sepsis-associated Hypotension

Safety and Effectiveness of Cartiva Implant in the Treatment of First CMC Joint Osteoarthritis Compared to LRTI (GRIP 2)

Clinical Study to Assess the Pharmacokinetics, Safety and Tolerability of Single and Multiple Oral Doses of AFQ056 in Children With Fragile X Syndrome (FXS)

Combination of AUY922 With Trastuzumab in HER2+ Advanced Breast Cancer Patients Previously Treated With Trastuzumab

Masitinib in the Treatment of Patients With Severe Uncontrolled Asthma and Elevated Eosinophil Levels