Clinical Trials in Philadelphia

Showing 12001-12020 of 20,904 trials

S. Aureus Translocation From Skin and Nose to Periprosthetic Tissues

NCT04666532

Surgical site infections (SSI) are a significant clinical issue that requires the use of a great amount of resources. In particular, periprosthetic joint infections (PJIs) have potentially catastrophic effects on patients' health-related quality of life, function, healthcare costs, outcomes and medical implications. National surveillance estimates may under-report the true incidence and when considering the large number of total hip (THA) and total knee arthroplasty (TKA) procedures performed each year. Patients who have a high-level of nasal bacteria have been found to have a risk of surgical site infection that is three to six times the risk compared with noncarriers and low-level carriers. The association between a patient's nasal carriage of S. aureus, specifically MRSA, and PJI has been demonstrated in a systematic review and confirmed in recent cohort studies. While this association seems to be well accepted, no mechanistic explanation has been provided for this association.

Staphylococcus Aureus

Rothman Institute Orthopaedics200 participantsStarted Oct 2020

Philadelphia, Pennsylvania, United States

COMPLETEDPhase 1< 1 mile

Single and Multiple Dose Escalation Study to Assess the Safety and Tolerability of CJM112 in Psoriasis

NCT01828086

A randomized, double-blind, placebo and positive controlled, single and multiple dose study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of CJM112 in chronic plaque-type psoriasis patients. This trial never made it to the Phase II part of this trial.

Chronic Plaque-type Psoriasis

Novartis Pharmaceuticals95 participantsStarted Jun 2013

Anniston, Alabama, United States • Anaheim, California, United States • Encino, California, United States +15 more locations

S. Aureus Translocation From Skin and Nose to Periprosthetic Tissues

Single and Multiple Dose Escalation Study to Assess the Safety and Tolerability of CJM112 in Psoriasis

Find Trials by Condition in Philadelphia

Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas

PET/CT in Psoriatic Arthritis

Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location

Pharmacokinetics of Dabrafenib in Subjects With Hepatic Impairment

Investigate Effect of Secukinumab on the PK of Midazolam in Patients With Mod to Sev Plaque Psoriasis

An Efficacy and Safety Study of BG00011 in Participants With Idiopathic Pulmonary Fibrosis

Effect of Mu-opioid Receptor Genetics on 3 Doses of Spinal Morphine for Postoperative Analgesia After Cesarean Section

Phase 1b Trial of BGJ398/BYL719 in Solid Tumors

A Phase I Study for Safety and Tolerability of AL002.

Twenty-Four Month Extension Study of BA058-05-003 (Abaloparatide) in Participants With Osteoporosis

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Dose CFZ533 in Rheumatoid Arthritis Patients

The CDR Implementation Trial

A Study of MEK162 and AMG 479 in Patients With Selected Solid Tumors

Exploratory Study of KPI-121 Effect on Intra- or Subretinal Fluid Due to Retinal Vein Occlusion/Diabetic Macular Edema

A Study to Investigate Safety, Pharmacokinetics (PK) and Pharmacodynamics (PD) of BKM120 Plus GSK1120212 in Selected Advanced Solid Tumor Patients

Nilotinib and LDE225 in the Treatment of Chronic or Accelerated Phase Myeloid Leukemia in Patients Who Developed Resistance to Prior Therapy

Safety, Tolerability, and Efficacy Study of CLL442 in Patients With Cutaneous Squamous Cell Carcinoma in Situ (SCCis)

Study to Evaluate the Pharmacokinetics of Tenofovir Alafenamide (TAF) in Adults With Normal Hepatic Function and Adults With Severe Hepatic Impairment