Clinical Trials in Philadelphia

Showing 9401-9420 of 20,904 trials

SLSMDS Natural History Study

NCT05029843

The Single Large-Scale mtDNA Deletion Sydrome: Natural History Study (PS-NHS) aims to collect data on standardized clinical outcomes, store data on the Champ Foundation Registry (CFR) and make this data available to researchers, clinicians, and industry partners who are studying SLSMDS to answer questions regarding the disease, including its causes, potential treatments, and other topics. A secondary aim is to analyze the data to understand research questions relating to the natural history of SLSMDS.

Pearson SyndromeSingle Large Scale Mitochondrial DNA Deletion Syndromes (SLSMDS)

The Champ Foundation30 participantsStarted Mar 2021

Cleveland, Ohio, United States • Philadelphia, Pennsylvania, United States

COMPLETEDPhase 1/2< 1 mile

A First-in-Human Study of CDK-002 (exoSTING) in Subjects With Advanced/Metastatic, Recurrent, Injectable Solid Tumors

NCT04592484

This is a first-in-human, Phase 1/2 open-label, multicenter, dose escalation, safety, pharmacodynamic, and PK study of CDK-002 in subjects with advanced/metastatic, recurrent, injectable solid tumors, whose disease has progressed despite receiving standard of care treatment. CDK 002 will be administered intratumorally (IT). Part A will enroll subjects with advanced/metastatic, recurrent, injectable solid tumors with emphasis on head and neck squamous cell cancer (HNSCC), triple negative breast cancer (TNBC), anaplastic thyroid carcinoma (ATC) and cutaneous squamous cell carcinoma (cSCC).

Advanced Solid Tumor

Codiak BioSciences27 participantsStarted Sep 2020

Scottsdale, Arizona, United States • New York, New York, United States • Philadelphia, Pennsylvania, United States +5 more locations

SLSMDS Natural History Study

A First-in-Human Study of CDK-002 (exoSTING) in Subjects With Advanced/Metastatic, Recurrent, Injectable Solid Tumors

Find Trials by Condition in Philadelphia

Study of BMS-936558 (Nivolumab) Compared to Docetaxel in Previously Treated Metastatic Non-squamous NSCLC

Phase II Trial of Doxil, Carboplatin, Bevacizumab in Triple Negative Untreated Metastatic Breast Cancer

A Study of Gantenerumab in Participants With Mild Alzheimer Disease

Efficacy, Safety and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type

Comparison of Rectal Trumpet and Standard Care

A Research Study to Compare Two Doses of Semaglutide Taken Once Weekly in People With Type 2 Diabetes

Evaluate the Response to 2 Induction Courses (12 Intravesical Instillations) of Bacillus Calmette-Guérin (BCG) for High Risk Superficial Bladder Cancer

Cytochrome C Oxidase Activity in Newly Diagnosed Glioblastoma Multiforme (GBM)

Study of Evinacumab (REGN1500) in Participants With Persistent Hypercholesterolemia

Pneumonia in the ImmunoCompromised - Use of the Karius Test for the Detection of Undiagnosed Pathogens

A Crossover Study Evaluating 3 Non-medicated Silicone IVRs

Study Evaluating the Mechanism of Action of PF-04965842 Monotherapy for Moderate-to-severe Atopic Dermatitis

A Study Of Oral PF-02341066, A C-Met/Hepatocyte Growth Factor Tyrosine Kinase Inhibitor, In Patients With Advanced Cancer

Improving Quality by Maintaining Accurate Problems in the EHR

Natural History and Biology of Long-Term Late Effects Following Hematopoietic Cell Transplant for Childhood Hematologic Malignancies

Evaluating an Emergency Department Observation Syncope Protocol for Older Adults

Web-based Implementation for the Science of Enhancing Resilience Study

Study In Women And Men With Metastatic Breast Cancer That Have Overexpression Of ErbB2