Clinical Trials in Philadelphia

Showing 8141-8160 of 20,904 trials

Study in Subjects With Small Primary Choroidal Melanoma

NCT03052127

The primary objective is to assess the safety, immunogenicity and efficacy of one of three dose levels and repeat dose regimens of Light-activated AU-011 and one or two laser applications for the treatment of subjects with primary choroidal melanoma.

Uveal MelanomaOcular MelanomaChoroidal Melanoma

Aura Biosciences57 participantsStarted Feb 2017

Tucson, Arizona, United States • Los Angeles, California, United States • Palo Alto, California, United States +10 more locations

TERMINATEDPhase 1< 1 mile

PRT1419 as Monotherapy or in Combination With Azacitidine or Venetoclax in R/R Myeloid or B-cell Malignancies

NCT05107856

This is a Phase 1 dose-escalation study of PRT1419, a myeloid cell leukemia-1 (MCL-1) inhibitor, in participants with selected relapsed/refractory myeloid or B-cell malignancies. The purpose of this study is to evaluate the safety and tolerability of PRT1419 monotherapy and in combination with either azacitidine or venetoclax, describe any dose limiting toxicities (DLTs), define the dosing schedule, and to determine the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D).

Acute Myeloid LeukemiaB-cell Non-Hodgkin LymphomaChronic Lymphocytic Leukemia+7 more

Prelude Therapeutics21 participantsStarted Mar 2022

Orange City, Florida, United States • Orlando, Florida, United States • Bethesda, Maryland, United States +6 more locations

Study in Subjects With Small Primary Choroidal Melanoma

PRT1419 as Monotherapy or in Combination With Azacitidine or Venetoclax in R/R Myeloid or B-cell Malignancies

Find Trials by Condition in Philadelphia

Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas

A Study of Melphalan Flufenamide (Melflufen)-Dex or Pomalidomide-dex for RRMM Patients Refractory to Lenalidomide

Study of SNX281 in Subjects With Advanced Solid Tumors and Lymphoma

A Study of CART-TnMUC1 in Patients With TnMUC1-Positive Advanced Cancers

Evaluation of Dupilumab in Patients With Atopic Keratoconjunctivitis (AKC)

Epicardial Delivery of XC001 Gene Therapy for Refractory Angina Coronary Treatment (The EXACT Trial)

Observational Study of the Safety of Intravenous Artesunate Treatment of Pregnant Women and Their Infants

The Acute Burn ResUscitation Multicenter Prospective Trial

Clinical Study Comparing the Efficacy and Safety of IDP-126 Gel in the Treatment of Acne Vulgaris

Ascertaining the Radiologic Prognostic Importance of Extranodal Extension on Imaging (iENE) in Head and Neck Cancer

Flotetuzumab in Primary Induction Failure (PIF) or Early Relapse (ER) Acute Myeloid Leukemia (AML)

Study to Evaluate the Efficacy and Safety of FX006 in Patients With Hip Osteoarthritis

Study of FX006 for the Treatment of Pain in Patients With Osteoarthritis of the Knee

Precision Crohn's Disease Management Utilizing Predictive Protein Panels (ENvISION)

Optimizing Video Communication Assessment for Teaching Error Disclosure Skills

A Dose-escalation, Expansion Study of ARX788, in Advanced Solid Tumors Subjects With HER2 Expression (ACE-Pan Tumor 01)

Study to Assess the Efficacy and Safety of MEDI3506 in Adults With Uncontrolled Moderate-to-severe Asthma

Study on Efficacy and Safety of LNP023 in C3 Glomerulopathy Patients Transplanted and Not Transplanted