Precision Crohn's Disease Management Utilizing Predictive Protein Panels (ENvISION)

Exclusion Criteria

• •1. Any prior treatment with an anti-TNF, such as infliximab, adalimumab, certolizumab or golimumab
• •2. Known diagnosis of ulcerative colitis (UC) or inflammatory bowel disease-unspecified (IBD-U)
• •3. Active or prior evidence of internal (abdominal/pelvic) penetrating fistula(e)
• •4. Active intra-abdominal abscess or perianal abscess
• •5. Active Clostridium difficile infection or other known enteric infection in last 2 weeks
• •6. Current ileostomy or colostomy, extensive small bowel resection, ileoanal pouch or short bowel syndrome
• •7. History of autoimmune disease (including autoimmune hepatitis, primary sclerosing cholangitis, thyroiditis, psoriasis or juvenile idiopathic arthritis)
• •8. Any condition that in the opinion of the PI will prevent the research participant from taking part in this study
• •Phase I - Cross-sectional Study (healthy volunteers)
• •1. Known diagnosis of one or more of the following: irritable bowel syndrome, gastroesophageal reflux, constipation, BMI\>95% for age, small intestinal bacterial overgrowth (SIBO) or history of intestinal polyps
• •2. Received any antibiotic in the last 30 days or known viral or bacterial illness in the last 30 days
• •3. Any NSAID use in the last 14 days
• •4. History of an autoimmune disease (including diabetes, autoimmune hepatitis, primary sclerosing cholangitis, thyroiditis, psoriasis or juvenile idiopathic arthritis)
• •5. Any condition that in the opinion of the PI will prevent the research participant from taking part in this study
• •Phase II - Longitudinal Study of Participants with CD
• •1. Crohn's disease limited to esophagus, stomach, duodenum or jejunum
• •2. Prior treatment with infliximab, adalimumab, certolizumab or golimumab
• •3. Known diagnosis of Ulcerative colitis (UC) or inflammatory bowel disease-unspecified (IBD-U)
• •4. Active or prior evidence of internal (abdominal/pelvic) penetrating fistula(e)
• •5. Active intra-abdominal abscess or perianal abscess
• •6. Active Clostridium difficile infection or other known enteric infection in last 2 weeks
• •7. Current ileostomy or colostomy, extensive small bowel resection, ileoanal pouch or short bowel syndrome
• •8. History of autoimmune disease (including autoimmune hepatitis, primary sclerosing cholangitis, thyroiditis, psoriasis or juvenile idiopathic arthritis)
• •9. Contraindications to MRI scanning, such as metal implants/non-compatible medical devices or medical conditions
• •10. Any condition that in the opinion of the PI will prevent the research participant from taking part in this study