Clinical Trials in Philadelphia

Showing 241-260 of 17,926 trials

Conversational AI Platform for Early Pregnancy Care City-wide Recruitment: A Feasibility Study

NCT07197892

This study seeks to determine pregnant patients in the Philadelphia area can be recruited to a conversational AI texting platform. The trial will be considered feasible if recruitment goals are met in proportion to delivery volume at the hospital.

Early Pregnancy

University of Pennsylvania2,637 participantsStarted Apr 2026

Philadelphia, Pennsylvania, United States

RECRUITINGPhase 3< 1 mile

Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)

NCT06393374

This is a randomized, open-label study comparing the efficacy and safety of adjuvant sacituzumab tirumotecan (MK-2870) in combination with pembrolizumab compared to treatment of physician's choice (TPC) in participants with triple-negative breast cancer (TNBC) who received neoadjuvant therapy and did not achieve a pathological complete response (pCR) at surgery. The primary objective is to compare sacituzumab tirumotecan plus pembrolizumab to TPC (pembrolizumab or pembrolizumab plus capecitabine) with respect to invasive disease-free survival (iDFS) per investigator assessment. It is hypothesized that sacituzumab tirumotecan plus pembrolizumab is superior to TPC with respect to iDFS per investigator assessment.

Triple-Negative Breast Cancer

Merck Sharp & Dohme LLC1,530 participantsStarted Jun 2024

Mobile, Alabama, United States • Chandler, Arizona, United States • Fountain Valley, California, United States +284 more locations

Conversational AI Platform for Early Pregnancy Care City-wide Recruitment: A Feasibility Study

Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)

Find Trials by Condition in Philadelphia

Pyruvate Kinase Deficiency Global Longitudinal Registry

Comparing Radiation Therapy to Usual Treatment for Patients With High-Risk Bone Metastases That Are Not Causing Pain, PREEMPT Trial

Global Open-Label Extension Study of Del-desiran for the Treatment of DM1

Study of Suratadenoturev (OBP-301) in Combination With Pembrolizumab in Esophagogastric Adenocarcinoma

Electrical Stimulation for the Treatment of Glaucoma

A Study of KT-621 Administered Orally to Participants With Moderate to Severe Atopic Dermatitis

A Pilot Trial of "Just ASK™" to Increase Discussions About Breast Cancer Clinical Trials

Relacorilant With Nab-Paclitaxel and Gemcitabine in Patients With Metastatic Pancreatic Adenocarcinoma

A Study Comparing Personalized Radiation Therapy With Standard Radiation Therapy in People With HPV-Positive Throat Cancer

A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30)

Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)

ACTEMRA® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma

A Study to Assess Safety, Tolerability and Preliminary Efficacy of Bexmarilimab in Combination With Standard of Care in Patients With Hematological Malignancies

Romosozumab as an Adjunct to Physiologic Estrogen Replacement in Functional Hypothalamic Amenorrhea

A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia

Long-term Safety and Efficacy Study of Riliprubart in Participants With CIDP

Investigation of Femoropopliteal In Situ Valve Formation With the InterVene System