Clinical Trials in Philadelphia

Showing 2461-2480 of 17,926 trials

Study BT7480-100 in Patients With Advanced Malignancies Associated With Nectin-4 Expression

NCT05163041

This clinical study is evaluating a drug called BT7480 alone and in combination with nivolumab in participants with advanced solid tumors associated with Nectin-4 expression. The main goals of the study are to: * Find the recommended dose of BT7480 that can be given safely to participants alone and in combination with nivolumab * Learn about the side effects and effectiveness of BT7480 alone and in combination with nivolumab * Learn about the effect BT7480 has on the body and how BT7480 is cleared by the body * Learn about the side effects and effectiveness of BT7480 in patients with reduced kidney function

Advanced Solid Tumor

BicycleTx Limited200 participantsStarted Nov 2021

Iowa City, Iowa, United States • New York, New York, United States • Cleveland, Ohio, United States +6 more locations

RECRUITING< 1 mile

Evaluation of Outcome Metrics in Alexander Disease

NCT02714764

The purpose of this study is to define the natural history of Alexander Disease, a leukodystrophy that causes neurological dysfunction. Investigators will obtain clinical outcome assessments to measure how the disease affects a patient's gross motor, fine motor, speech and language function, swallowing, and quality of life. Specimens are collected to measure glial fibrillary acidic protein (GFAP) levels in cerebrospinal fluid (CSF) and blood. The data obtained from this study will be used for the design of future treatment trials.

Alexander Disease

Children's Hospital of Philadelphia200 participantsStarted Jan 2016

Philadelphia, Pennsylvania, United States

Study BT7480-100 in Patients With Advanced Malignancies Associated With Nectin-4 Expression

Evaluation of Outcome Metrics in Alexander Disease

Find Trials by Condition in Philadelphia

Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Participants With Endometrial Cancer After Platinum-Based Chemotherapy and Immunotherapy (ASCENT-GYN-01/GOG-3104/ENGOT-en26)

Assessment of CCM in HF With Higher Ejection Fraction

Sacituzumab Govitecan +/- Pembrolizumab In HR+ / HER2 - MBC

An Open-Label Extension Study of GSK3511294 (Depemokimab) in Participants Who Were Previously Enrolled in 206713 (NCT04719832) or 213744 (NCT04718103)

Study of Acute Normovolemic Hemodilution (ANH) in People With Ovarian Cancer Who Are Having Cytoreductive Surgery

A Study of Glipizide to Treat High Blood Sugar in People With Pancreatic Cancer

Meaning-Centered Counseling for Chinese Patients Who Are Being Treated for Advanced Cancer

Immunotherapy With MK-3475 in Surgically Resectable Head and Neck Squamous Cell Carcinoma

IN10018 Monotherapy and Combination Therapy for Metastatic Melanoma

A Phase 1b/2, Multi-center, Single Arm Study to Assess the Safety and Efficacy of Neoantigen Synthetic Long Peptide Vaccines in Patients With Local Or Metastatic Solid Tumors

A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma

Use of the REGENETEN™ Bioinductive Implant System in High Grade Partial-thickness Tears

A Phase III, Safety, Tolerability and Efficacy of Combination Treatment of BL-8040 and Granulocyte Colony Stimulating Factor (G-CSF) as Compared to Placebo and G-CSF for the Mobilization of Hematopoietic Stem Cells for Autologous Transplantation in Subjects With Multiple Myeloma (MM)

A Study of DM005 in Patients With Advanced Solid Tumors

Prostate Active Surveillance Study

VECTORS - A Study to Evaluate Transmural Healing as a Treatment Target in Crohn's Disease

Randomized, Open-label, Two-arms, Phase III Comparative Study Assessing the Role of Involved Mediastinal Radiotherapy After Rituximab Containing Chemotherapy Regimens to Patients With Newly Diagnosed Primary Mediastinal Large B-Cell Lymphoma

Clinical Assessment of Pharmacokinetics, Efficacy, and Safety of 10% IVIg in Pediatric PID Patients (KIDCARES10)