Clinical Trials in Pennsylvania

Showing 5721-5740 of 19,675 trials

Does Switching to Nicotine Containing Electronic Cigarettes Reduce Health Risk Markers

NCT03625986

The overall goal of this project is to understand the likely health effects of cigarette smokers switching to a Standardized Research Electronic Cigarette (SREC) and to assess the role of nicotine delivery on switching and acceptability as well as markers of health outcomes. Current smokers who meet all eligibility criteria will completely switch from their combustible (regular) cigarettes to an electronic cigarette (SREC) that either contains 58 mg/ml of nicotine or 0 mg/ml of nicotine in the liquid. The investigators' hypothesis is that attempting to switch to a SREC will result in a reduction in markers of harms to health, as compared with the baseline (smoking) measures. The investigators also hypothesize that nicotine-containing SRECs will facilitate switching from smoking more efficiently than zero nicotine SRECs and will result in a significantly greater improvement in markers of health risk, but will result in higher ratings of dependence on the SREC (as compared to the zero nicotine SREC).

Tobacco Dependence

Milton S. Hershey Medical Center105 participantsStarted Apr 2022

Hershey, Pennsylvania, United States

RECRUITINGNA50 miles

Use of an Intrauterine Manipulator and Its Correlation with Positive Peritoneal Cytology in Early Stage Endometrial Cancers

NCT04570553

This study aims to answer whether use of a Vcare® intrauterine manipulator leads to an increased incidence of positive peritoneal cytology in patients undergoing surgical management of early stage (FIGO stage I/II) endometrial cancer.

Endometrial Cancer

WellSpan Health350 participantsStarted Oct 2020

York, Pennsylvania, United States

Does Switching to Nicotine Containing Electronic Cigarettes Reduce Health Risk Markers

Use of an Intrauterine Manipulator and Its Correlation with Positive Peritoneal Cytology in Early Stage Endometrial Cancers

Find Trials by Condition in Pennsylvania

Endometrial Cancer Recurrence in Patients Taking Metformin

A Study to Evaluate the Efficacy and Safety of Oral Zavegepant in Migraine Prevention

A Study to Evaluate Whether Macitentan is an Effective and Safe Treatment for Patients With Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease

Study of MK-3475 (Pembrolizumab) in Patients With Microsatellite Unstable (MSI) Tumors (Cohort D)

Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder

Sunitinib Malate in Treating Patients With Thyroid Cancer That Did Not Respond to Iodine I 131 and Cannot Be Removed by Surgery

Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight Infants

Safety, Tolerability, and Pharmacokinetics of Oral Treprostinil in Pediatric PAH Patients Aged 7 to 17 Years

Safety and Efficacy of Repeat Administration of Ad/PNP and Fludarabine Phosphate in Patients With Local Head/Neck Cancer

Vitamin D to ENhance TraUma REcovery

A Study of Real-life Current Standards of Care in Patients With Relapsed and/or Refractory Multiple Myeloma Who Received at Least 3 Prior Lines of Therapy Including Proteasome Inhibitor (PI), Immunomodulatory Drug (IMID), and Cluster of Differentiation 38 (CD38) Monoclonal Antibody Treatment

Electrical Muscle Stimulation with 1064 Nm Diode Laser and RF/PEMF for Non-invasive Body Contouring and Fat Reduction.

Outcome of Patients with Severe Functional TR According to Medical, Transcatheter or Surgical Treatment

Long-term Study of Semapimod (CNI-1493) for Treatment of Crohn's Disease

A Study of MGD020 Alone or Combined With MGD014 in Persons With HIV-1 on Antiretroviral Therapy

Treatment of Hyperphagia Behavioral Symptoms in Children and Adults Diagnosed With Prader-Willi Syndrome

TRAC-ER Intervention to Reduce Risky Alcohol Use and HIV Risk

Antibiotic Prophylaxis Before Shock Wave Lithotripsy