Clinical Trials in Ohio

Showing 8701-8720 of 20,938 trials

A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens

NCT03953235

The purpose of this study is to evaluate the dose, safety, immunogenicity and early clinical activity of GRT-C903 and GRT-R904, a neoantigen-based therapeutic cancer vaccine, in combination with immune checkpoint blockade, in patients with advanced or metastatic non-small cell lung cancer, microsatellite stable colorectal cancer, pancreatic cancer, and shared neoantigen-positive tumors. Based on the Phase 1 data, an updated vaccine candidate (SLATE-KRAS or version 2) was developed that removed 16 of the 20 mutations included in the original vaccine (version 1) and solely targets KRAS mutations.

Non-Small Cell Lung CancerColorectal CancerPancreatic Cancer+2 more

Gritstone bio, Inc.39 participantsStarted Jul 2019

Phoenix, Arizona, United States • Santa Monica, California, United States • Jacksonville, Florida, United States +9 more locations

COMPLETEDPhase 332 miles

Safety & Efficacy of Pilocarpine Ophthalmic Spray for Temporary Improvement of Near Vision in Presbyopic Adults

NCT05114486

Volunteer participants are evaluated for eligibility during a Screening Visit; those meeting study inclusion/exclusion criteria are scheduled for 2 treatment visits. At each treatment visit, 1 of the 2 study treatments is self-administered to both eyes. Afterwards, efficacy and safety assessments are performed over a 3-hour period.

Presbyopia

Eyenovia Inc.145 participantsStarted Nov 2021

San Diego, California, United States • Fairfield, Connecticut, United States • Louisville, Kentucky, United States +6 more locations

A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens

Safety & Efficacy of Pilocarpine Ophthalmic Spray for Temporary Improvement of Near Vision in Presbyopic Adults

Find Trials by Condition in Ohio

Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Failure (ADHF) and Renal Insufficiency

Real World Evaluation of the Effectiveness of AZD7442 for Prevention of SARS-CoV-2

Observation or Radiation Therapy in Treating Patients With Grade I, Grade II, or Grade III Meningioma

A Long-Term Extension Trial in Participants With Atopic Dermatitis Who Participated in Previous EDP1815 Trials

A Study of Duvelisib in Participants With Refractory Indolent Non-Hodgkin Lymphoma

Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis

Study of the Safety and Efficacy of PRX-102 Compared to Agalsidase Beta on Renal Function

Dociparstat Sodium (CX-01) Combined With Standard Induction Therapy for Newly Diagnosed Acute Myeloid Leukemia

An Investigation of the Safety of 4 Different Doses of Autologous Muscle Derived Cells as Therapy for Stress Urinary Incontinence

A Study of NTX-001 in the Treatment and Prevention of Facial Paralysis Requiring Surgical Repair.

A Study to Evaluate the Abuse Potential of Oxymorphone Compared to Other Mu Opioid Agonists.

PCI Treatment/Gemcitabine & Chemotherapy vs Chemotherapy Alone in Patients With Inoperable Extrahepatic Bile Duct Cancer

Dose-Ranging Efficacy and Safety Study of Topical Rapamycin Cream for Facial Angiofibroma Associated With Tuberous Sclerosis Complex

Safety and Immunotherapeutic Activity of Cemiplimab in Participants With HBV on Suppressive Antiviral Therapy

Norepinephrine Transporter Blockade, Autonomic Failure (NETAF)

Efficacy and Safety of Orally Administered BBT-401-1S in Subjects With Ulcerative Colitis

Primary Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

PEP on a Skin Graft Donor Site Wound