Clinical Trials in North Carolina

Showing 9741-9760 of 20,428 trials

Pilot Study of Loop Diuretics Among Individuals Receiving Hemodialysis

NCT04622709

Individuals with kidney failure receiving maintenance hemodialysis (HD) have high mortality rates, driven largely by cardiovascular causes. Volume-related factors are critical, modifiable contributors to cardiovascular complications. Reversing volume overload has been shown to improve blood pressure and cardiac remodeling. Use of loop diuretics may represent a pragmatic, low-cost, and low-burden strategy to improve outcomes in people receiving HD. Lack of data on optimal furosemide dosing, safety, and acceptability are barriers to expanded use. This study investigates whether oral furosemide is safe and effective at increasing urine volume in HD patients.

Chronic Kidney Disease Requiring Chronic Dialysis

University of North Carolina, Chapel Hill39 participantsStarted Oct 2020

Carrboro, North Carolina, United States • Pittsboro, North Carolina, United States • Sanford, North Carolina, United States +2 more locations

COMPLETEDPhase 341 miles

Radiation Therapy With or Without Bicalutamide for Recurrent pT3N0 Prostate Cancer After Radical Prostatectomy

NCT00002874

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Androgens can stimulate the growth of prostate cancer cells. Hormone therapy using bicalutamide may fight prostate cancer by reducing the production of androgens. It is not yet known if radiation therapy is more effective with or without bicalutamide for prostate cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy with or without bicalutamide in treating patients who have stage II or stage III prostate cancer and elevated prostate-specific antigen (PSA) levels following radical prostatectomy.

Prostate Cancer

Radiation Therapy Oncology Group840 participantsStarted Feb 1998

Birmingham, Alabama, United States • Huntsville, Alabama, United States • Huntsville, Alabama, United States +237 more locations

Pilot Study of Loop Diuretics Among Individuals Receiving Hemodialysis

Radiation Therapy With or Without Bicalutamide for Recurrent pT3N0 Prostate Cancer After Radical Prostatectomy

Find Trials by Condition in North Carolina

Study of the Efficacy and Safety of Bupivacaine TTS Patch in Patients With Chronic Low Back Pain

Assessment In a Real World Setting of the Effect of Inhaled Steroid-based Triple Therapy Versus the Combination of Tiotropium and Olodaterol on Reducing Chronic Obstructive Pulmonary Disease (COPD) Exacerbations [AIRWISE]

Dapagliflozin in Respiratory Failure in Patients With COVID-19

Multi-dose Pharmacokinetics and Dose Ranging of Inositol in Premature Infants (INS-2)

Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Kidney Transplant Recipients

Study of Aztreonam for Inhalation in Children With Cystic Fibrosis and New Infection of the Airways by Pseudomonas Aeruginosa Bacteria

Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis (PsA)

Efficacy, Safety, and Pharmacokinetic Profiles of REGN3500 Administered to Adult Patients With Moderate-to-Severe Atopic Dermatitis

Avelumab in First-Line Maintenance Gastric Cancer (JAVELIN Gastric 100)

Surgical Idiopathic Intracranial Hypertension Treatment Trial

Chemotherapy and Radiation Therapy in Treating Patients With Stage II or Stage III Bladder Cancer That Was Removed by Surgery

International BPA Registry

Pilot Study of Denosumab in BRCA1/2 Mutation Carriers Scheduled for Risk-Reducing Salpingo-Oophorectomy

Clinical Validation of New OCT System

Evaluation of the Efficacy and Safety of Sarilumab in Patients With Polymyalgia Rheumatica

Safety and Performance of ENTACT Septal Staple System for Septoplasty

A Study to Assess the Effectiveness of the Nautilus BrainPulse™ as an Aid in the Diagnosis of Concussion

Reducing Barriers and Sustaining Utilization of a Cervical Cancer Screening Program in Rural Senegal