Clinical Trials in New York State

Showing 4761-4780 of 17,167 trials

Safety, Tolerability and Pharmacokinetics Study of KPG-818 in Hematological Malignancies Subjects

NCT04283097

This is a phase 1, multicenter, open-label, multiple-ascending dose study to evaluate the safety, pharmacokinetics and clinical activity of KPG-818 in subjects with hematological malignancies. Approximately 30 patients will be enrolled for dose escalation of 4 dose levels. Indication: Hematological malignancies (multiple myeloma \[MM\], mantle cell lymphoma \[MCL\], diffuse large B-cell lymphoma \[DLBCL\], adult T-cell leukemia-lymphoma \[ATL\], and indolent non Hodgkin lymphomas such as follicular lymphoma \[FL\] and chronic lymphocytic leukemia \[CLL\]/small lymphocytic lymphoma \[SLL\]).

Hematological Malignancies

Kangpu Biopharmaceuticals, Ltd.30 participantsStarted Sep 2021

Sacramento, California, United States • Plantation, Florida, United States • Louisville, Kentucky, United States +7 more locations

Active Not RecruitingPhase 2/398 miles

A Study of a Patient-Specific Neoantigen Vaccine in Combination With Immune Checkpoint Blockade for Patients With Metastatic Colorectal Cancer

NCT05141721

The primary objective of the Phase 2 portion of the study is to characterize the clinical activity of maintenance therapy with GRT-C901/GRT-R902 (patient-specific vaccines) in combination with checkpoint inhibitors in addition to fluoropyrimidine/bevacizumab versus a fluoropyrimidine/bevacizumab alone as assessed by molecular response which is based on changes in circulating tumor (ct)DNA. The primary objective of the Phase 3 portion is to demonstrate clinical efficacy of the regimen as assessed by progression-free survival.

Colorectal Neoplasms

Seattle Project Corporation700 participantsStarted Feb 2022

Gilbert, Arizona, United States • Springdale, Arkansas, United States • Los Angeles, California, United States +40 more locations

Safety, Tolerability and Pharmacokinetics Study of KPG-818 in Hematological Malignancies Subjects

A Study of a Patient-Specific Neoantigen Vaccine in Combination With Immune Checkpoint Blockade for Patients With Metastatic Colorectal Cancer

Find Trials by Condition in New York State

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

Improve New Learning and Memory in Individuals With Mild Cognitive Impairment

Efficacy, Safety and Tolerability of Balcinrenone/Dapagliflozin Compared to Dapagliflozin in Adults With Chronic Kidney Disease

Study of TH-302 or Placebo in Combination With Pemetrexed in Patients With Non-squamous Non-small Cell Lung Cancer

A Study of CFI-400945 With or Without Azacitidine in Patients With AML, MDS or CMML

Study of Safety and Efficacy of Novel Immunotherapy Combinations in Patients With Triple Negative Breast Cancer (TNBC).

First-in-Human Study of RLY-5836 in Advanced Breast Cancer and Other Solid Tumors

Cognition and Imaging With Tigertriever

7-week Study With CT-155 in People With Schizophrenia

Dose-Ranging Study of ST-920, an AAV2/6 Human Alpha Galactosidase A Gene Therapy in Subjects With Fabry Disease (STAAR)

A Study of Long-term Effect of Dupilumab on Skin Barrier Function in Pediatric Participants With Atopic Dermatitis

Natural Versus Programmed Frozen Embryo Transfer (NatPro)

Early Integrated Telehealth Versus In-Person Palliative Care for Patients With Lung Cancer

Pulmonary Embolism International THrOmbolysis Study-3

Neurobiology of Functional Movement Disorder and Non-Epileptic Seizures

Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response

Study of Safety, Efficacy and Tolerability of Secukinumab Versus Placebo, in Combination With SoC Therapy, in Patients With Active Lupus Nephritis

Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Liver Transplant Recipients With Additional 12-month Follow-up and Long-term Extension