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Discover 17,885 clinical trials near Houston, Texas. Find research studies in your area.
Showing 11121-11140 of 17,885 trials
NCT02640573
Sickle cell disease (SCD), specifically hemoglobin SC disease (HbSC), is a subtype of sickle cell disease with typically higher hemoglobin and milder or later disease complications. Sickle cell disease is a disorder in which red blood cells (RBCs) are abnormally shaped. This can result in painful episodes, serious infections, and damage to body organs. One medication used to treat sickle cell disease is hydroxyurea. Hydroxyurea therapy offers significant benefits for infants, children, and adolescents with sickle cell anemia. These include a reduction in the frequency of pain crises and acute chest syndrome (inflammation of the lungs). Hydroxyurea has been given to many HbSC patients but HbSC patients were not included in the large clinical trials used to test hydroxyurea in SCD, so less is known about how HbSC patients respond to hydroxyurea. The purpose of this research study is to see if hydroxyurea, a medication given to many patients with the most common type of sickle cell, those who are homozygous for the sickle mutation (HbSS), helps individuals who have HbSC. The investigators will see if it helps by giving a questionaire when the medication is started, and then every two months at a clinic visit. The questionaire, called the AdultsQLTM 3.0 Sickle Cell Disease Module, measures quality of life. The investigators will also see how hydroxyurea changes laboratory test numbers, and blood thickness.
NCT00823498
The aims of the proposed study are to: 1. Examine how youth and their parents use and perceive three active living domains for physical activity (PA): schools, recreation, and transportation environment; 2. Identify patterns and predictors of environmental perceptions of physical activity; 3. Compare and contrast youth evaluations of physical activity resources with research team objective evaluations of physical activity resources; 4. Using above data, refine the conceptual framework of physical activity phenomena in low-income minority communities guiding this research and develop items for a quantitative survey measuring parental and youth environmental perceptions of physical activity for a future trial with this population.