Lead Sponsor

Bristol-Myers Squibb

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com.
•Subjects with advanced or metastatic solid tumors (non-hematologic refractory to or relapsed from standard therapies or for which there is no known effective treatment during dose escalation
•Subjects with squamous non-small cell lung cancer and triple-negative breast cancer or other solid tumor types for which Notch activation has been demonstrated (such as pancreatic, ovarian and melanoma) during dose expansion
•Biopsy accessible tumor (may be waived under certain circumstances)
•Life expectancy of at least 3 months
•Eastern Cooperative Oncology Group (ECOG) 0-1
•Adequate organ and bone marrow function

•Infection
•Elevated triglycerides
•Gastrointestinal (GI) disease with increased risk of diarrhea \[e.g. inflammatory bowel disease (IBD)\]
•Taking medications known to increase risk of Torsades De Pointes