Clinical Trials in Detroit

Showing 7841-7860 of 19,719 trials

Molecular Mechanisms of Antipsychotic-induced Insulin Resistance

NCT02708394

This study will investigate the molecular mechanisms of atypical-antipsychotic induced insulin resistance. This will be accomplished by administering olanzapine or placebo to healthy subjects for 7 days and analyzing genetic and protein changes in peripheral tissues known to play an important role in insulin resistance pathophysiology.

Adverse Effect of Other Antipsychotics and NeurolepticsInsulin Resistance

Wayne State University31 participantsStarted Feb 2017

Detroit, Michigan, United States

TERMINATEDPhase 3< 1 mile

A Study of MEK162 vs. Physician's Choice Chemotherapy in Patients With Low-grade Serous Ovarian, Fallopian Tube or Peritoneal Cancer

NCT01849874

The MILO Study (MEK Inhibitor in Low-grade Serous Ovarian Cancer) is a Phase 3 study during which patients with recurrent or persistent low-grade serous (LGS) carcinomas of the ovary, fallopian tube or primary peritoneum will receive either investigational study drug MEK162 or a chemotherapy chosen by the physician (liposomal doxorubicin, paclitaxel or topotecan). Patients will be followed to compare the effectiveness of the study drug to that of the selected chemotherapies. Patients may be eligible to crossover from physician's choice chemotherapy to MEK162 if they meet certain inclusion criteria including centrally confirmed disease progression. Approximately 360 patients from North America, Europe and Australia will be enrolled in this study.

Low-grade Serous Ovarian CancerLow-grade Serous Fallopian Tube CancerLow-grade Serous Peritoneal Cancer

Pfizer341 participantsStarted Jun 2013

Phoenix, Arizona, United States • Phoenix, Arizona, United States • Scottsdale, Arizona, United States +223 more locations

Molecular Mechanisms of Antipsychotic-induced Insulin Resistance

A Study of MEK162 vs. Physician's Choice Chemotherapy in Patients With Low-grade Serous Ovarian, Fallopian Tube or Peritoneal Cancer

Find Trials by Condition in Detroit

Gallium-68 PSMA-11 PET in Patients With Biochemical Recurrence

Michigan Medicine COVID-19 Cohort: Clinical Characteristics, Inflammatory Markers and Outcomes of Patients Hospitalized for COVID-19

A Study to Test Whether Different Doses of BI 456906 Help People With Overweight or Obesity to Lose Weight

Efficacy and Safety of Sirolimus in LAM

Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Osteoarthritis

Flecainide Acetate Inhalation Solution for Cardioversion of Recent-Onset, Symptomatic Atrial Fibrillation

Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Diabetic Peripheral Neuropathic Pain

Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Chronic Low Back Pain

Saline-Controlled Study of nSTRIDE APS for Knee Osteoarthritis

Clinical Comparison of Two Daily Disposable Toric Soft Contact Lenses

A Safety and Efficacy Evaluation of BLI801 Laxative in Adults Experiencing Non-Idiopathic Constipation

Efficacy and Safety of Reparixin in Pancreatic Islet Auto-transplantation

Aerosolized Infasurf Treatment Protocol: Aerosolized Infasurf for Spontaneously Breathing Patients With Early RDS (AERO-03)

Humacyte Human Acellular Vessel (HAV) in Patients With Vascular Trauma

A Phase 1 Study of Ruxolitinib, Steroids and Lenalidomide for Relapsed/Refractory Multiple Myeloma (RRMM) Patients

The Lung Screening, Tobacco and Health Project

A Study Evaluating the Safety, Pharmacokinetics and Efficacy of Ipatasertib Administered in Combination With Rucaparib in Participants With Advanced Breast, Ovarian Cancer, and Prostate Cancer.

PK/PD Study of Vicagrel and Clopidogrel in Healthy Subjects With Different CYP2C19 Metabolizers