Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Chronic Low Back Pain

Exclusion Criteria

• •Have second or third-degree atrioventricular (AV) heart block or AV dissociation or history of ventricular tachycardia.
• •Have had a procedure within the past 6 months intended to produce permanent sensory loss in the target area of interest (for example, ablation techniques).
• •Have surgery planned during the study for any reason, related or not to the disease state under evaluation.
• •Have, in the judgment of the investigator, an acute, serious, or unstable medical condition or a history or presence of any other medical illness that would preclude study participation.
• •There is an inability to rule out other causative or confounding sources of pain in the primary condition under study.
• •Have had cancer within 2 years of baseline, except for cutaneous basal cell or squamous cell carcinoma resolved by excision.
• •Have a substance use disorder as defined by the Diagnostic and Statistical Manual of Mental Disorders (5th edition; DSM-5; American Psychiatric Association).
• •Have congenital QT prolongation or QT interval corrected for heart rate using Fridericia's formula (QTcF) interval measurement \>450 milliseconds (msec) for male participants, \>470 msec for female participants, or \>480 msec for participants with bundle branch block.
• •Have any clinically important abnormality at screening, as determined by investigator, in physical or neurological examination, vital signs, electrocardiogram (ECG), or clinical laboratory test results that could be detrimental to the participant or could compromise the study.
• •Have a positive human immunodeficiency virus (HIV) test result at screening.
• •Are, in the judgment of the investigator, actively suicidal and therefore deemed to be at significant risk for suicide.
• •Have an intolerance to acetaminophen or paracetamol or any of its excipients.
• •Have a history of alcohol, illicit drug, analgesic or narcotic use disorder within 2 years prior to screening.
• •Have used a therapeutic injection (botulinum toxin or corticosteroids) in the 3 months prior to starting the washout period.
• •Have history of or current osteoporotic compression fracture.
• •Have had a recent major trauma (within 6 months of baseline).
• •Have had surgical intervention for the treatment of low back pain in the past 6 months.
• •Have a history within 2 years prior to screening or current evidence of syncope, presyncope, uncontrolled vertigo, or postural dizziness, judged to be clinically significant by the investigator.
• •Have clinically significant active thyroid disease, including Hashimoto's thyroiditis.
• •Are taking metformin therapy.
• •Are pregnant or breastfeeding.