Clinical Trials in Chicago

Showing 4341-4360 of 20,493 trials

Metabolic Mechanisms Induced by Enteral DHA and ARA Supplementation in Preterm Infants

NCT05380401

A comprehensive analysis of the impact of exogenous enteral DHA and ARA supplementation on lipid metabolism including the production of downstream derived mediators and how this impacts important biological pathways such as metabolism, inflammation, and organogenic factors.

Premature

The University of Texas Health Science Center at San Antonio328 participantsStarted Mar 2023

Los Angeles, California, United States • New Haven, Connecticut, United States • Chicago, Illinois, United States +4 more locations

RECRUITINGPhase 12.2 miles

A Study of BH-30236 in Relapsed/ Refractory Acute Myelogenous Leukemia and Higher Risk Myelodysplastic Syndrome

NCT06501196

Study BH-30236-01 is a first-in-human (FIH), Phase 1/1b, open-label, dose escalation and expansion study in participants with relapsed/refractory acute myelogenous leukemia (R/R AML) or higher-risk myelodysplastic syndrome (HR-MDS). Phase 1, Part 1 Dose Escalation - Monotherapy will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary efficacy of BH-30236 administered orally. Approximately 50 participants may be enrolled in Phase 1, Part 1 Dose Escalation - Monotherapy. Phase 1, Part 2 Dose Escalation - Combination with Venetoclax will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary efficacy of BH-30236 administered as a combination therapy with venetoclax. Approximately 48 participants may be enrolled in Phase 1, Part 2 Dose Escalation - Combination with Venetoclax. Phase 1b (Dose Expansion) will follow Phase 1 to further understand the relationships among dose, exposure, toxicity, tolerability, and clinical activity. Up to 72 participants may be enrolled in Phase 1b of the study as a monotherapy or in combination with venetoclax.

LeukemiaLeukemia, MyeloidLeukemia, Myeloid, Acute+3 more

BlossomHill Therapeutics170 participantsStarted Jun 2024

Duarte, California, United States • Los Angeles, California, United States • Palo Alto, California, United States +10 more locations

Metabolic Mechanisms Induced by Enteral DHA and ARA Supplementation in Preterm Infants

A Study of BH-30236 in Relapsed/ Refractory Acute Myelogenous Leukemia and Higher Risk Myelodysplastic Syndrome

Find Trials by Condition in Chicago

Study to Evaluate Safety and Efficacy of VX-661 in Combination With Ivacaftor in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation With an Open-Label Expansion

Study of OCA in Combination With BZF Evaluating Efficacy, Safety and Tolerability in Participants With PBC

Investigational Extended Wear Insulin Infusion Set in People With Type 1 Diabetes

A Study to Evaluate the Efficacy and Safety of BLI5100 in Patients With Erosive Esophagitis

Study on Two Adjuvanted Dose Levels of Panblok H7+MF59 Compared for Immunogenicity and Safety With an Unadjuvanted Dose of Panblok H7 in Participants 18 Years of Age and Older

NTX-301 in MDS/AML

Phase 2a Study of VX-147 in Adults With APOL1-mediated Focal Segmental Glomerulosclerosis

First In Human Study With ABBV-CLS-579 When Given Alone and In Combination In Participants With Locally Advanced Or Metastatic Tumors

Using the Multiphase Optimization Strategy to Adapt Cognitive Processing Therapy

To Assess the Pharmacokinetics and Safety and Tolerability of Efanesoctocog Alfa (BIVV001)in Adults With Type 2N and 3 Von Willebrand Disease (VWD)

A Study to Evaluate Safety and Efficacy of Empasiprubart in Adults With Dermatomyositis

A Study of AZD3427 in Participants With Heart Failure and Pulmonary Hypertension Group 2

Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipients

A Clinical Trial on Safety and Efficacy of CBT-001 in Patients With Pterygium

ENCALM: A Study of ENX-102 as a Monotherapy Treatment in Patients With Generalized Anxiety Disorder

Natural History and Biospecimen Acquisition for Children and Adults With Rare Solid Tumors

Phase1/2a Study for IPG7236 in Patients With Advanced Solid Tumors

A Study to Evaluate ELX/TEZ/IVA on Cough and Physical Activity in Participants With Cystic Fibrosis (CF)