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Clinical Trials in California | 11,359 Studies Near You | Clareo Health

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Clinical Trials in California

Discover 11,359 clinical trials near California. Find research studies in your area.

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Breast Cancer Lung Cancer Prostate Cancer Colorectal Cancer Melanoma Leukemia Lymphoma Pancreatic Cancer

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Showing 5461-5480 of 11,359 trials

COMPLETED63 miles

Mobile Cardiac Telemetry and Advanced Multi-Parameter Monitoring in Patients

NCT04754204

To determine the associations among biometric data, arrhythmias, subject-reported symptoms and subject wellness.

Cardiac Arrhythmia

Zoll Medical Corporation585 participantsStarted Dec 2020

Bakersfield, California, United States • Long Beach, California, United States • Los Angeles, California, United States +17 more locations

UNKNOWN117 miles

Performance of the Dexcom Continuous Glucose Monitoring (CGM) System in Pregnant Women With Diabetes Mellitus

NCT04905628

Performance of the Dexcom Continuous Glucose Monitoring (CGM) System in Pregnant Women With Diabetes Mellitus

Diabetes Mellitus

DexCom, Inc.100 participantsStarted Jul 2021

Santa Barbara, California, United States • Aurora, Colorado, United States • Boston, Massachusetts, United States +2 more locations

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Breast Cancerin California Lung Cancerin California Prostate Cancerin California Colorectal Cancerin California Melanomain California Leukemiain California Lymphomain California Pancreatic Cancerin California Ovarian Cancerin California Brain Cancerin California

Data from ClinicalTrials.govTerms

TERMINATEDPhase 3129 miles

Efficacy and Safety of Amantadine Hydrogen Chloride (HCl) ER Tablets in Parkinson's Disease Subjects With LID

NCT02153632

The purpose of this multi-center, randomized, double-blind, parallel-group, 26 week study is to compare the efficacy and safety of two different dose levels of Amantadine Extended Release Tablets to placebo for the treatment of levodopa induced dyskinesia in patients with Parkinson's disease.

Parkinson's DiseaseLevodopa Induced Dyskinesia (LID)

Adamas Pharmaceuticals, Inc.135 participantsStarted Jul 2014

Tucson, Arizona, United States • Fountain Valley, California, United States • Irvine, California, United States +53 more locations

TERMINATEDPhase 3143 miles

COVID-19 Positive Outpatient Thrombosis Prevention in Adults Aged 40-80

NCT04498273

A multi-center adaptive randomized placebo-controlled platform trial evaluating the efficacy and safety of anti-thrombotic strategies in COVID-19 adults not requiring hospitalization at time of diagnosis

Frank C Sciurba657 participantsStarted Sep 2020

Los Angeles, California, United States • Palo Alto, California, United States • San Francisco, California, United States +68 more locations

COMPLETEDPhase 3146 miles

A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes

NCT03987919

The reason for this study is to compare the effect of the study drug tirzepatide to semaglutide on blood sugar levels in participants with type 2 diabetes. The study will last approximately 47 weeks and may include about 12 visits.

Type 2 Diabetes

Eli Lilly and Company1,879 participantsStarted Jul 2019

Birmingham, Alabama, United States • Sheffield, Alabama, United States • Huntington Park, California, United States +124 more locations

UNKNOWNPhase 2/3156 miles

NA-831, Atazanavir and Dexamethasone Combination Therapy for the Treatment of COVID-19 Infection

NCT04452565

This Phase 2/3 trial evaluates four treatment strategies for non-critically ill hospitalized participants (not requiring ICU admission and/or mechanical ventilation) with SARS CoV-2 infection, in which participants will receive NA-831 or Atazanavir with or without Dexamethasone.

Coronavirus InfectionSevere Acute Respiratory InfectionSevere Acute Respiratory Syndrome Coronavirus 2

Biomed Industries, Inc.525 participantsStarted Jun 2022

Los Angeles, California, United States • Orange, California, United States • Palo Alto, California, United States +28 more locations

COMPLETEDPhase 1/2158 miles

S0727 Gemcitabine Hydrochloride and Erlotinib Hydrochloride With or Without Monoclonal Antibody Therapy in Treating Patients With Metastatic Pancreatic Cancer That Cannot Be Removed By Surgery

NCT00617708

This randomized phase I/II trial is studying the side effects and best dose of monoclonal antibody therapy when given together with gemcitabine hydrochloride and erlotinib hydrochloride and to see how well they work compared with giving gemcitabine hydrochloride and erlotinib hydrochloride alone as first-line therapy in treating patients with metastatic pancreatic cancer that cannot be removed by surgery. Drugs used in chemotherapy, such as gemcitabine hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Erlotinib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Giving erlotinib hydrochloride and gemcitabine hydrochloride together with monoclonal antibody therapy may kill more tumor cells.

Stage IV Pancreatic Cancer

National Cancer Institute (NCI)134 participantsStarted Mar 2008

Jonesboro, Arkansas, United States • Berkeley, California, United States • Burlingame, California, United States +143 more locations

TERMINATEDPhase 2159 miles

X-82 to Treat Age-related Macular Degeneration

NCT02348359

The purpose of this study is to evaluate the safety and efficacy of X-82 in the treatment of vision loss due to wet AMD.

Age-Related Macular Degeneration (AMD)Macular DegenerationExudative Age-related Macular Degeneration+5 more

Tyrogenex157 participantsStarted Mar 2015

Tucson, Arizona, United States • Beverly Hills, California, United States • Huntington Beach, California, United States +32 more locations

COMPLETEDPhase 3160 miles

A Study to Evaluate the Efficacy and Safety of Remdesivir Plus Tocilizumab Compared With Remdesivir Plus Placebo in Hospitalized Participants With Severe COVID-19 Pneumonia

NCT04409262

This study will evaluate the efficacy and safety of combination therapy with remdesivir plus tocilizumab compared with remdesivir plus placebo in hospitalized patients with COVID-19 pneumonia.

COVID-19 Pneumonia

Hoffmann-La Roche649 participantsStarted Jun 2020

Phoenix, Arizona, United States • Chula Vista, California, United States • Irvine, California, United States +51 more locations

COMPLETEDPhase 1/2164 miles

Study to Explore the Safety, Tolerability and Efficacy of MK-3475 in Combination With INCB024360 in Participants With Selected Cancers

NCT02178722

The purpose of this study was to assess the safety, tolerability, and efficacy when combining MK-3475 and INCB024360 in participants with certain cancers. This study was conducted in 2 phases, Phase 1 and Phase 2.

Microsatellite-instability (MSI) High Colorectal Cancer (CRC)Endometrial CancerHead and Neck Cancer+11 more

Incyte Corporation444 participantsStarted Jul 2014

La Jolla, California, United States • Los Angeles, California, United States • Sacramento, California, United States +21 more locations

COMPLETEDNA165 miles

Continuous Glucose Monitoring and Insulin Pump Therapy in Diabetic Gastroparesis

NCT01030341

A pilot study to assess the safety, feasibility, and potential (uncontrolled) efficacy of continuous glucose monitoring (CGMS) in conjunction with an insulin pump to improve glycemic control for treatment of type 1 and type 2 diabetic patients with gastroparesis

Diabetic Gastroparesis

Johns Hopkins Bloomberg School of Public Health45 participantsStarted May 2011

San Francisco, California, United States • Stanford, California, United States • Ann Arbor, Michigan, United States +4 more locations

COMPLETEDPhase 3167 miles

Efficacy and Safety of Adult Human Mesenchymal Stem Cells to Treat Steroid Refractory Acute Graft Versus Host Disease (GVHD)

NCT00366145

The purpose of this study is to evaluate the efficacy and gather additional safety information for Prochymal® in participants who have failed to respond to steroid treatment of Grades B-D acute GVHD.

Graft Versus Host Disease

Mesoblast, Inc.260 participantsStarted Aug 2006

Birmingham, Alabama, United States • Tucson, Arizona, United States • Duarte, California, United States +67 more locations

COMPLETEDPhase 3178 miles

5-Year Safety Study of Pimecrolimus Cream 1% in Infants 3 - 12 Months of Age With Mild to Moderate Atopic Dermatitis

NCT00120523

The primary purpose of this study is to investigate the safety of pimecrolimus cream 1% in the long-term treatment (up to 5 years) of atopic dermatitis (eczema) in patients less than 12 months of age compared to topical corticosteroids (TCS).

Atopic Dermatitis

MEDA Pharma GmbH & Co. KG2,418 participantsStarted Apr 2004

Phoenix, Arizona, United States • Tucson, Arizona, United States • Little Rock, Arkansas, United States +28 more locations

COMPLETEDPhase 3187 miles

Herniorrhaphy Study for Opioid Elimination

NCT03907176

This is a Phase 3b, open-label study to assess postoperative opioid use in subjects undergoing unilateral open inguinal herniorrhaphy with intraoperative administration of HTX-011 and a postoperative non-opioid multimodal analgesic (MMA) regimen. The study will be conducted in 2 sequential parts: Part 1 is randomized and Part 2 is Investigator's preference for MMA regimen.

Heron Therapeutics115 participantsStarted Apr 2019

Anaheim, California, United States • La Mesa, California, United States • La Mesa, California, United States +27 more locations

COMPLETEDPhase 2187 miles

Multi-Dose Safety/Pharmacodynamic Study of SEL-212/SEL-037 in Subjects With Symptomatic Gout & Elevated Blood Uric Acid

NCT02959918

This is an open label multicenter study to evaluate the safety and tolerability of multiple doses (3 monthly IV infusions) of SEL-212 ( a combination of pegsiticase (SEL-037) and SVP-rapamycin (SEL-110)) followed by multiple doses (2 monthly IV infusions) of pegsiticase (SEL-037) alone for a total of 5 treatment cycles in subjects with symptomatic gout and hyperuricemia. Additional participants will be treated with multiple doses ( 5 monthly IV infusions) of pegsiticase (SEL-037) alone. Participants will be monitored for safety endpoints through the 5th treatment cycle plus 30 days .Pharmacokinetic samples will be drawn at pre-determined time points in addition to weekly serum uric acid levels.

Gout ChronicHyperuricemia

Selecta Biosciences, Inc.152 participantsStarted Oct 2016

Anaheim, California, United States • El Cajon, California, United States • Irvine, California, United States +10 more locations

TERMINATEDPhase 1197 miles

A Study Evaluating the Safety and Pharmacokinetics of Atezolizumab Administered in Combination With Hu5F9-G4 to Patients With Relapsed and/or Refractory Acute Myeloid Leukemia

NCT03922477

This Phase Ib study is designed to evaluate the safety and pharmacokinetics of atezolizumab when given in combination with Hu5F9-G4 to patients with relapsed or refractory (R/R) acute myeloid leukemia (AML).

Acute Myeloid Leukemia

Hoffmann-La Roche13 participantsStarted Oct 2019

Sacramento, California, United States • New Haven, Connecticut, United States • New York, New York, United States +1 more locations

COMPLETEDPhase 2197 miles

Lenalidomide in Treating Older Patients With Acute Myeloid Leukemia

NCT00352365

This phase II trial is studying how well lenalidomide works in treating older patients with acute myeloid leukemia with abnormal chromosome 5q. Biological therapies, such as lenalidomide, may stimulate the immune system in different ways and stop cancer cells from growing.

Adult Acute Basophilic LeukemiaAdult Acute Eosinophilic LeukemiaAdult Acute Megakaryoblastic Leukemia (M7)+14 more

National Cancer Institute (NCI)41 participantsStarted Jun 2006

Little Rock, Arkansas, United States • Redding, California, United States • Roseville, California, United States +51 more locations

No Longer Available275 miles

Expanded Access Remdesivir (RDV; GS-5734™)

NCT04302766

Disease caused by 2019 Novel Coronavirus also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Coronavirus Disease 2019

U.S. Army Medical Research and Development Command

San Diego, California, United States • Jacksonville, Florida, United States • Fort Benning, Georgia, United States +19 more locations

COMPLETEDPhase 2668 miles

Copanlisib in Treating Patients With Persistent or Recurrent Endometrial Cancer

NCT02728258

This phase II trial studies how well copanlisib works in treating patients with endometrial cancer that has not decreased or disappeared, and the cancer may still be in the body despite treatment (persistent) or has come back (recurrent). Copanlisib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Endometrial Endometrioid AdenocarcinomaEndometrial Mixed Cell AdenocarcinomaEndometrial Serous Adenocarcinoma+3 more

NRG Oncology11 participantsStarted Sep 2016

New Haven, Connecticut, United States • Deerfield Beach, Florida, United States • Miami, Florida, United States +40 more locations

COMPLETEDPhase 2838 miles

Study to Evaluate Tezepelumab on Airway Inflammation in Adults With Uncontrolled Asthma (CASCADE)

NCT03688074

A phase 2, multicentre, randomized, double-blind, placebo-controlled, parallel group study to evaluate the effect of tezepelumab on airway inflammation in adults with inadequately controlled asthma.

AsthmaBronchial DiseasesRespiratory Tract Diseases+6 more

AstraZeneca116 participantsStarted Nov 2018

Denver, Colorado, United States • New Haven, Connecticut, United States • Boston, Massachusetts, United States +25 more locations

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