Clinical Trials in Boston

Showing 1401-1420 of 15,299 trials

Alisertib With or Without Fulvestrant in Treating Patients With Locally Advanced or Metastatic, Endocrine-Resistant Breast Cancer

NCT02860000

This phase II trial studies how well alisertib with or without fulvestrant works in treating patients with endocrine-resistant breast cancer that has spread to other places in the body. Alisertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Hormone therapy using fulvestrant may fight breast cancer by blocking the use of estrogen by the tumor cells or reducing the amount of estrogen made by the body. Giving alisertib with or without fulvestrant may be better in treating patients with breast cancer.

Estrogen Receptor StatusHER2/Neu NegativeInvasive Breast Carcinoma+6 more

Mayo Clinic96 participantsStarted Jul 2017

Washington D.C., District of Columbia, United States • Boston, Massachusetts, United States • Ann Arbor, Michigan, United States +5 more locations

TERMINATEDPhase 2< 1 mile

MBG453 in Lower Risk MDS

NCT04823624

This research study is assessing the efficacy of MBG-453, a humanized monoclonal antibody, in treating myelodysplastic syndromes (MDS). The name of the study drug involved in this study is MBG453.

Myelodysplastic Syndromes

Massachusetts General Hospital10 participantsStarted Jan 2022

Boston, Massachusetts, United States • Boston, Massachusetts, United States • Boston, Massachusetts, United States

Alisertib With or Without Fulvestrant in Treating Patients With Locally Advanced or Metastatic, Endocrine-Resistant Breast Cancer

MBG453 in Lower Risk MDS

Find Trials by Condition in Boston

Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS

Mobile Health and Social Media Physical Activity Intervention Among Adolescent and Young Adult Childhood Cancer Survivors, the StepByStep Study

Star Matrix vs Autogenous Graft for Gingival Augmentation: Split-Mouth RCT

Positron Emission Tomography (PET) Imaging of Thrombosis

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use

Study to Assess the Effect of Ofatumumab in Treatment Naïve, Very Early RRMS Patients Benchmarked Against Healthy Controls.

Study Comparing Combination of LGX818 Plus MEK162 Versus Vemurafenib and LGX818 Monotherapy in BRAF Mutant Melanoma

A Trial of Etelcalcetide in Pediatric Participants With Secondary Hyperparathyroidism and Chronic Kidney Disease on Hemodialysis

Open-Label Extension of EryDex Study IEDAT-04-2022

Stratification and Treatment in Early Psychosis Study - PROMOTE

A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer

Defining Clinical Endpoints in Limb Girdle Muscular Dystrophy (LGMD)

A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Anti-tumour Activity of IPN01203 in Adults With Locally Advanced or Metastatic Solid Tumours Exposed to Immune Checkpoint Inhibitor Therapies

A Study to Compare Safety and Efficacy of High Doses of Eteplirsen in Participants With Duchenne Muscular Dystrophy (DMD) (MIS51ON)

Study of Novel Treatment Combination Therapies in Participants With Head and Neck Squamous Cell Carcinoma Regardless of PD-L1 Expression Status; Substudy-01

A Post Approval Multicenter 10 Year Follow-up Observational Trial of Marketed Product - MP01 vs. Surgical Standard of Care (SSOC) Used for the Treatment of Joint Surface Lesions of the Knee