Study to Assess the Effect of Ofatumumab in Treatment Naïve, Very Early RRMS Patients Benchmarked Against Healthy Controls.

Exclusion Criteria

• •1. Confounding medical condition as determined by the investigator
• •2. Diseases other than multiple sclerosis responsible for the clinical or MRI presentation
• •3. Patients with neuromyelitis optica, Radiologic/ Clinically Isolated Syndrome, Secondary Progressive or Primary Progressive MS diagnosis
• •4. Use of experimental or investigational drugs for MS
• •5. Previous use of Disease Modifying Therapy (DMT) or chemotherapeutic medications for MS
• •6. Relapse between screening and Baseline visits
• •7. Known sensitivity to gadolinium; patients with chronic, severe kidney disease
• •8. Known history of hypersensitivity to any of the study treatments or its excipients or to drugs of similar chemical classes
• •9. CNS anomalies that are better accounted for by another disease process or MRI anomalies causing clinically apparent impairments
• •10. Known active malignancies
• •11. Pregnant or nursing (lactating) women
• •12. Females of childbearing potential (all women physiologically capable of becoming pregnant) should use effective contraception while receiving ofatumumab and for 6 months after the last treatment of ofatumumab
• •13. Patients with an active chronic disease (or stable but treated with immune therapy) of the immune system other than MS or with immunodeficiency syndrome
• •14. Patients with active infections including systemic bacterial, viral (including SARS-CoV-2/COVID-19) or fungal infections, or known to have AIDS or to test positive for HIV antibody at Screening
• •15. Patients with neurological findings consistent with Progressive Multifocal Leukoencephalopathy (PML), or confirmed PML
• •16. Patients with IgG or IgM levels below LLN at Screening
• •17. Patients that have received any live or live-attenuated vaccines within 4 weeks prior to first dose of study drug administration
• •18. Patients at risk of developing or having reactivation of hepatitis