Clinical Trials in Boston

Showing 8061-8080 of 17,836 trials

CHOEP + High Dose Therapy + Auto SCT for T-Cell Lymphoma

NCT01746173

The current standard of care for the frontline treatment of peripheral T-cell lymphomas (PTCL) is induction chemotherapy followed by autologous stem cell transplantation (ASCT). However, many patients are unable to get to ASCT or relapse after ASCT, with a poor prognosis. Recently, a novel ASCT conditioning regimen of gemcitabine, busulfan and melphalan (Gem/Bu/Mel) has been reported to lead to favorable outcomes in this disease. We therefore designed a frontline regimen of CHOEP induction followed by Gem/Bu/Mel ASCT, and report the results of a phase 2 study of this regimen in patients with PTCL.

T-cell Non-Hodgkin Lymphoma

Dana-Farber Cancer Institute5 participantsStarted Jul 2013

Boston, Massachusetts, United States • Boston, Massachusetts, United States

COMPLETEDPhase 1/2< 1 mile

Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for Hospitalized Adult Patients With COVID-19

NCT04426695

The primary objectives are: Pooled Phase 3 (Cohort 1) and Phase 2 (Cohort 1A) * To evaluate the virologic efficacy of REGN10933+REGN10987 compared to placebo in reducing viral load of SARS-CoV-2 * To evaluate the clinical efficacy of REGN10933+REGN10987 compared to placebo, as measured by death or mechanical ventilation Phase 1/2 (Cohort 1) * To exclude futility of REGN10933+REGN10987 compared to placebo, as measured by death or mechanical ventilation * To evaluate the safety and tolerability of REGN10933+REGN10987 compared to placebo

COVID-19

Regeneron Pharmaceuticals2,252 participantsStarted Jun 2020

Birmingham, Alabama, United States • Chandler, Arizona, United States • Phoenix, Arizona, United States +120 more locations

CHOEP + High Dose Therapy + Auto SCT for T-Cell Lymphoma

Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for Hospitalized Adult Patients With COVID-19

Find Trials by Condition in Boston

Desmoid Tumor and Pregnancy: Effect of Pregnancy on Disease Control and Effect of Diagnosis on Pregnancy History.

Lenalidomide and Pidilizumab in Treating Patients With Relapsed or Refractory Multiple Myeloma

Gabapentin as a Pre-emptive Analgesic in Oral and Maxillofacial Surgical Procedures

Study Evaluating the Efficacy and Safety of Selinexor (KPT-330) in Participants With Recurrent Gliomas

CAR T-CELL Therapy Educational Video Trial

Exercise Trial in Chronic Kidney Disease

Oxygen Versus PAP for Sleep Apnea in Heart Failure

Efficacy of EsoGuard Assay on Esophageal Surface Cells Collected With EsoCheck vs EGD for the Diagnosis of BE or EAC

Methadone and Medication Abortion

Exercise Maintenance in Chronic Pain and PTSD

Effectiveness and Safety of BMS-986165 Compared to Placebo and Active Comparator in Participants With Psoriasis

Using ANDS to Reduce Harm for Low SES Cigarette Smokers

Study Tests Whether a Standardized LVR Performed With the Blue Egg Device Improves Cardiopulmonary Exercise Capacity

Safety Study of KPT-330 (Selinexor) in Patients With Advanced or Metastatic Solid Tumor Cancer

Neuro RX Gamma - Pivotal Phase

Outcome pRognostication of Acute Brain Injury With the NeuroloGical Pupil indEx

Cholangioscopy in Primary Sclerosing Cholangitis (PSC)

Coronavirus Disease (COvid-)19 REgistry on THROMBOSIS Complications