Clinical Trials in Boston

Showing 501-520 of 15,299 trials

A Phase 2 Study of Belzutifan (PT2977, MK-6482) for the Treatment of Von Hippel Lindau (VHL) Disease-Associated Renal Cell Carcinoma (RCC) (MK-6482-004)

NCT03401788

This study is designed to investigate belzutifan as a treatment for VHL disease associated RCC.

VHL - Von Hippel-Lindau SyndromeVHL Gene MutationVHL Syndrome+3 more

Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)50 participantsStarted May 2018

Bethesda, Maryland, United States • Boston, Massachusetts, United States • Ann Arbor, Michigan, United States +8 more locations

Active Not RecruitingPhase 2< 1 mile

A Follow-on Study for Second-Eye Treatment for Participants Previously Treated With Gene Therapy for X-Linked Retinitis Pigmentosa (XLRP)

NCT06646289

The purpose of this study is to assess the safety and tolerability of subretinal delivery of Adeno-associated Virus Vector (AAV5 hRKp.RPGR) gene therapy in adults and children with X-linked retinitis pigmentosa.

X-Linked Retinitis Pigmentosa

Janssen Research & Development, LLC24 participantsStarted Oct 2024

Boston, Massachusetts, United States • Ann Arbor, Michigan, United States • London, United Kingdom

A Phase 2 Study of Belzutifan (PT2977, MK-6482) for the Treatment of Von Hippel Lindau (VHL) Disease-Associated Renal Cell Carcinoma (RCC) (MK-6482-004)

A Follow-on Study for Second-Eye Treatment for Participants Previously Treated With Gene Therapy for X-Linked Retinitis Pigmentosa (XLRP)

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Testing the Addition of a New Anti-cancer Drug, Radium-223 Dichloride, to the Usual Treatment (Cabozantinib) for Advanced Renal Cell Cancer That Has Spread to the Bone, RadiCaL Study

A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma

A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma

Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation

Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study

Comparing the Safety and Efficacy of Apixaban and Rivaroxaban

Botensilimab, Balstilimab, and SBRT in Colorectal Cancer

A Study to Evaluate the Efficacy and Safety of ESK-001 in Patients With Moderate to Severe Plaque Psoriasis

Adjuvant Nivolumab & Low Dose Ipilimumab for Stage III & Resected Stage IV Melanoma

Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

Pazopanib Hydrochloride in Treating Patients With Progressive Carcinoid Tumors

A Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study

Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib

Post-trial Access Program of Idursulfase-IT Along With Elaprase in Children With Hunter Syndrome

Micro-UltraSound In Cancer - Active Surveillance

A Study to Assess the Efficacy and Safety of Vatiquinone for the Treatment of Participants With Friedreich Ataxia

GYNEMESH PS Mesh Post Marketing Clinical Follow-Up Study

A Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of TT125-802 in Subjects With Advanced Solid Tumors