Clinical Trials in Boston

Showing 4861-4880 of 17,836 trials

Rucaparib in Combination With Nivolumab in Patients With Advanced or Metastatic Biliary Tract Cancer Following Platinum Therapy

NCT03639935

Investigators hypothesize that following first-line platinum based chemotherapy, rucaparib in combination with nivolumab, will improve progression-free survival and overall survival in BTC patients.

Biliary Tract Cancer

University of Michigan Rogel Cancer Center32 participantsStarted Mar 2019

Boston, Massachusetts, United States • Ann Arbor, Michigan, United States • Nashville, Tennessee, United States

COMPLETEDPhase 1< 1 mile

Study to Assess the Safety, Tolerability, Pharmacokinetics and Immunogenicity of AK006 in Healthy Subjects and Subjects With Chronic Spontaneous Urticaria

NCT06072157

This is a Phase 1, randomized, double-blind, placebo-controlled, sequential, single- and multiple-ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK), and immunogenicity of intravenous (IV) infusions and a single subcutaneous (SC) injection of AK006. The study will be conducted in 4 parts: a single-ascending dose part (Part A) in healthy participants, a multiple-ascending dose part (Part B) in healthy participants with an expanded cohort (Part C) in participants with chronic spontaneous urticaria (CSU), and a single ascending dose SC injection cohort (Part D) in healthy participants.

Healthy ParticipantsChronic Spontaneous Urticaria

Allakos Inc.136 participantsStarted Aug 2023

Anniston, Alabama, United States • Birmingham, Alabama, United States • Scottsdale, Arizona, United States +22 more locations

Rucaparib in Combination With Nivolumab in Patients With Advanced or Metastatic Biliary Tract Cancer Following Platinum Therapy

Study to Assess the Safety, Tolerability, Pharmacokinetics and Immunogenicity of AK006 in Healthy Subjects and Subjects With Chronic Spontaneous Urticaria

Find Trials by Condition in Boston

Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions

Multi-Component Breath Alcohol Intervention Phase 3

Global Utilization And Registry Database for Improved heArt preservatioN

Early Feasibility Study of the RelayBranch Thoracic Stent-Graft System

Study of the Relay Pro® Thoracic Stent-Graft in Subjects With Traumatic Injury of the Descending Thoracic Aorta

Durvalumab, Tremelimumab + Radiotherapy in Gynecologic Cancer

Amped-PD: Amplifying Physical Activity Through Music in Parkinson Disease

Modulation Effects of Baduanjin Exercise on Subjective Cognitive Decline

RTA 408 Ophthalmic Suspension for the Prevention of Corneal Endothelial Cell Loss Following Cataract Surgery - GUARD

Shwachman-Diamond Syndrome Global Patient Survey and Partnering Platform

Sling vs Botox for Mixed Incontinence

Long Term Extension Trial of Setmelanotide

A Study of Insulin Efsitora Alfa (LY3209590) Compared With Insulin Degludec in Participants With Type 2 Diabetes Currently Treated With Basal Insulin

A Study to Evaluate Efficacy and Safety of Deucravacitinib in Participants With Alopecia Areata

A Safety, Efficacy And Pharmacokinetics Study Of Tofacitinib In Pediatric Patients With sJIA

Efficacy and Safety of GMRx2 Compared to Dual Combinations for the Treatment of Hypertension

PANTHER Study of Terumo Aortic Knitted and Woven Grafts, and Cardiovascular Patches

Efficacy and Safety of GMRx2 Compared to Placebo for the Treatment of Hypertension