Long Term Extension Trial of Setmelanotide

Exclusion Criteria

• •1. Pregnant and/or breastfeeding women
• •2. Significant dermatologic findings relating to melanoma or pre-melanoma skin lesions (excluding non-invasive basal or squamous cell lesion)
• •3. Current, clinically significant disease
• •4. Documented diagnosis of schizophrenia, bipolar disorder, personality disorder, major depressive disorder, or other psychiatric disorder(s)
• •5. Suicidal ideation, attempt or behavior
• •6. History of significant liver disease
• •7. Moderate to severe renal dysfunction as defined by a glomerular filtration rate (GFR)\<30 milliliters per minute (mL/min).
• •8. History or close family history of melanoma or participant history of oculocutaneous albinism