Clinical Trials in Boston

Showing 2921-2940 of 15,299 trials

Early Vedolizumab as First-Line for Immune-Related Colitis Therapy Trial

NCT06841705

The goal of this clinical trial is to compare the effectiveness and safety of Vedolizumab with a short course of steroids compared to standard course of steroids for the treatment of immune checkpoint inhibitor colitis (ICI colitis) in adults. The main questions it aims to answer are: * How many patients treated with Vedolizumab and a short course of steroids experience resolution of colitis at 8 weeks. * How many patients treated with a standard course of steroids experience resolution of colitis at 8 weeks. Participants will: Recieve 3 doses of Vedolizumab or a placebo (a look-alike substance that contains no drug) infusions over 6 weeks Receive intravenous Medrol daily for 3 days Receive Prednisone daily for 7 days Receive Prednisone or placebo taper daily Receive Sulfamethoxazole-Trimethoprim or placebo taper daily Weekly checkups and periodic tests

Immune Checkpoint Inhibitor-Related Colitis

Shilpa Grover, MD, MPH80 participantsStarted Jul 2025

Boston, Massachusetts, United States • Boston, Massachusetts, United States

TERMINATEDPhase 3< 1 mile

Phase III Trial to Investigate Efficacy and Safety of Vilobelimab in Ulcerative Pyoderma Gangrenosum

NCT05964413

A randomized, double-blind, placebo-controlled, multicenter, adaptive phase III trial to investigate efficacy and safety of vilobelimab in the treatment of ulcerative pyoderma gangrenosum

Pyoderma Gangrenosum

InflaRx GmbH54 participantsStarted Nov 2023

Hialeah, Florida, United States • Miami, Florida, United States • Orlando, Florida, United States +47 more locations

Early Vedolizumab as First-Line for Immune-Related Colitis Therapy Trial

Phase III Trial to Investigate Efficacy and Safety of Vilobelimab in Ulcerative Pyoderma Gangrenosum

Find Trials by Condition in Boston

NLP to Aid in the Evaluation and Diagnosis of FGIDs

Impact of Earplugs on Mechanisms of Noise-Related Cardiovascular Disease

Clinical Trial Evaluating ITI-007 (Lumateperone) as a Monotherapy for the Treatment of Bipolar Depression

ZILRETTA in Subjects With Shoulder Osteoarthritis

Operator and Patient Acceptance of Radiofrequency Cautery of the Biopsy Track During Percutaneous Liver, Kidney or Spleen Biopsy Procedures.

Developing Viability Index for Machine Perfused Livers

Self-regulation of Real-time fMRI Brain Activity in Chronic Pain

A Study to Assess Long-term Safety, Tolerability, and Efficacy of Rocatinlimab in Adult and Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD)

Waveform Capnography Compared to Colorimetric Carbon Dioxide Detection During Tracheal Intubation of Critically Ill Adults

Wireless Prosthetic Control Effectiveness Study

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

A Study to Describe the Characteristics, Health Care Interventions and Outcomes of Patients With Major Bleedings in the Presence of Factor Xa Inhibitor Treatment

Randomized Study Comparing Two Dosing Schedules for Hypofractionated Image-Guided Radiation Therapy

Oncolytic Adenovirus Coding for TNFa and IL2 (TILT-123) With Pembrolizumab or Pembrolizumab (Phase 1a) and Pegylated Liposomal Doxorubicin (Phase 1b) as Treatment for Ovarian Cancer.

Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)

A Modular Phase 1/2 Study With CT7439 in Participants With Solid Malignancies

A Clinical Study on New Negative Pressure Wound Therapy Dressing in the Management of Chronic & Acute Wounds

Sex-specific Risk Factors and Trajectories of Blood Biomarkers for Alzheimer's Disease and Related Dementias