Clinical Trials in Atlanta

Showing 14721-14740 of 19,805 trials

Phase II Study of VS-6063 in Patients With KRAS Mutant Non-Small Cell Lung Cancer

NCT01951690

This is a Phase II, open-label, multicenter, multi cohort, study of VS-6063 (defactinib), a focal adhesion kinase inhibitor, in patients with KRAS mutant non-small cell lung cancer (NSCLC). NSCLC with a KRAS mutation is required for study entry and subjects will be enrolled into 1 of 4 cohorts based on the status of their INK4a/Arf and p53 mutations. The purpose of this study is to demonstrate if VS-6063 (defactinib) improves PFS within each cohort. The safety and tolerability of VS-6063, tumor response rate, progression free survival and overall survival will also be assessed. The pharmacodynamic effects of VS-6063 (defactinib) will be examined in a tumor biopsy and a blood sample.

Non Small Cell Lung CancerLung Cancer

Verastem, Inc.55 participantsStarted Sep 2013

Denver, Colorado, United States • Atlanta, Georgia, United States • Baltimore, Maryland, United States +6 more locations

COMPLETEDPhase 3< 1 mile

Safety and Efficacy of Cariprazine for Bipolar I Disorder

NCT01058668

The objective of this study is to evaluate the efficacy, safety, and tolerability of cariprazine monotherapy versus placebo for the treatment of acute manic or mixed episodes associated with bipolar I disorder.

ManiaBipolar I Disorder

Forest Laboratories497 participantsStarted Feb 2010

Little Rock, Arkansas, United States • Cerritos, California, United States • Costa Mesa, California, United States +63 more locations

Phase II Study of VS-6063 in Patients With KRAS Mutant Non-Small Cell Lung Cancer

Safety and Efficacy of Cariprazine for Bipolar I Disorder

Find Trials by Condition in Atlanta

Safety and Efficacy of AVP-923 in PBA Patients With ALS or MS

A Study to Assess the Effect and Safety of AZD6765 in Patients With Major Depressive Disorder

Effect of NovoTTF-100A Together With Temozolomide in Newly Diagnosed Glioblastoma Multiforme (GBM)

Exemestane or Docetaxel-Cytoxan in Low Recurrence Score Cancers

A 12-Week Study in Asthmatic Children Ages 6 to <12 Years, Investigating the Efficacy and Safety of Symbicort pMDI 80/2.25 μg and Symbicort pMDI 80/4.5 μg, Compared With Budesonide pMDI 80 μg

Bipolar Disorder Study for Men and Women

Safety, Tolerability and Efficacy of Etelcalcetide in Hemodialysis Patients With Secondary Hyperparathyroidism

Chemotherapy With or Without Additional Chemotherapy and/or Radiation Therapy in Treating Children With Newly Diagnosed Hodgkin's Disease

Study of LY2784544 Testing Alternative Dosing in Participants With Myeloproliferative Neoplasms

Prolonging Remission in Depressed Elderly (PRIDE)

Progel Vascular Sealant

3-year Follow-up Study in Patients Previously Treated With TMC435-Containing Regimen for the Treatment of Hepatitis C Virus Infection

Depression in Alzheimer's Disease-2

Efficacy and Safety of 20 mg Sumatriptan Powder Delivered Intranasally With the Bi-directional Device Compared With 100 mg Sumatriptan Tablets in Adults With Acute Migraine With or Without Aura

Applying Platelet Rich Plasma (PRP) Gel to Acute Deep Partial Thickness Thermal Injuries

Brodalumab Drug-Drug Interaction (DDI) and Intensive Pharmacodynamic (PK) Study in Psoriasis Subjects

Hypothermia in Acute Stroke With Thrombolysis Imaging Evaluation of Revascularization

Phase IIA Double-Masked Randomized Sham-Controlled Trial of QPI-1007 Delivered by a Single Intravitreal Injection to Subjects With Acute Primary Angle-Closure Glaucoma (APACG)