Rheumatoid Arthritis Clinical Trials

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MDMA-Assisted Therapy for Veterans With PTSD and Alcohol Use Disorder

NCT07118839

The study investigators are conducting the first randomized placebo-controlled trial of MDMA-assisted therapy with a comorbid sample of military Veterans with a co-occurring diagnosis of Alcohol Use Disorder (AUD) and Post-Traumatic Stress Disorder (PTSD). This novel experimental treatment package consists of three once-monthly Experimental Sessions of therapy combined with a divided-dose of MDMA HCl, along with non-drug preparatory and integrative therapy. The primary objective of the proposed project is to evaluate safety and clinical outcomes of MDMA-assisted therapy compared to identical psychotherapy with low dose ("active placebo") MDMA for the treatment of PTSD-AUD in military Veterans. The Primary Outcome measures, the Clinician Administered PTSD Scale (CAPS-5) and Inventory of Psychosocial Functioning (IPF), will evaluate changes in PTSD symptoms and psychosocial outcomes over time. Changes in drinking outcomes will also be evaluated (via the Timeline Followback, TLFB).

Post Traumatic Stress DisorderAlcohol Use Disorder

VA Office of Research and Development80 participantsStarted Apr 2026

West Haven, Connecticut, United States • Providence, Rhode Island, United States

COMPLETEDNA

Dural Puncture Epidural vs Standard Epidural Analgesia in Labor

NCT07278895

This randomized prospective study compares Dural Puncture Epidural (DPE) and Standard Epidural Analgesia in term laboring women. The study evaluates analgesic quality, onset time, maternal and neonatal outcomes, side effects, and overall patient satisfaction.

Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital102 participantsStarted Jan 2026

Diyarbakır, Outside of the US, Turkey (Türkiye)

MDMA-Assisted Therapy for Veterans With PTSD and Alcohol Use Disorder

Dural Puncture Epidural vs Standard Epidural Analgesia in Labor

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