Rheumatoid Arthritis Clinical Trials

Showing 4941-4960 of 47,334 trials

Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study)

NCT04897802

Oxytocin (OT) is a hypothalamic peptide that enters the peripheral circulation via the posterior pituitary gland. OT plays a key role in regulating appetite, psychopathology, prosocial behavior and sexual function. Hypopituitarism is associated with increased obesity, increased psychopathology, sexual and prosocial dysfunction despite appropriate hormone replacement. A few studies suggest the existence of a possible OT deficient state in hypopituitarism. In animal models, glucagon-like peptide 1 (GLP1) has shown to increase OT release. This study is designed to evaluate OT values after administration of GLP1 in adults (healthy volunteers and patients with hypopituitarism). The investigators hypothesize that OT response will be blunted following GLP1 receptor agonist (GLP1-RA) in patients with hypopituitarism compared to healthy controls.

HypopituitarismCentral Diabetes InsipidusPanhypopituitarism+5 more

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau42 participantsStarted Sep 2021

Barcelona, Spain

RECRUITINGPhase 1

Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer

NCT06736379

The goal of this clinical trial is to assess the safety and tolerability of a virus replicon particle (VRP) encapsulated saRNA encoding IL-12 when injected into in head and neck cancer patients. The main questions being addressed are: The safety and tolerability of intratumoral (IT) injections of VRP-encapsulated saRNA encoding IL-12 (VLPONC-01) The tumor response to IT injections of VLPONC-01 The tumor response due to the combination of IT injections of VLPONC-01 and system IV administration of neoadjuvant pembrolizumab (anti-PD-1) treatment Researchers will compare neoadjuvant pembrolizumab alone to the combination therapy to see if the combination enhances tumor responses.

Head and Neck Cancers- Squamous CellHead and Neck CancerSolid Tumors+10 more

VLP Therapeutics41 participantsStarted May 2025

Stanford, California, United States

Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study)

Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer

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