Rheumatoid Arthritis Clinical Trials

Showing 301-320 of 40,629 trials

Tovorafenib for Treatment of Craniopharyngioma in Children and Young Adults

NCT05465174

The current study assesses the tolerability and efficacy of monotherapy with pan-RAF-kinase (Tovorafenib) inhibition for the treatment of children and young adults with craniopharyngioma.

Craniopharyngioma, ChildCraniopharyngiomaRecurrent Craniopharyngioma

Sabine Mueller, MD, PhD57 participantsStarted Sep 2022

Birmingham, Alabama, United States • San Diego, California, United States • San Francisco, California, United States +17 more locations

RECRUITINGPhase 2

SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy.

NCT06614322

The goal of this clinical trial is to determine whether quantitative sensory testing (QST) can be used to classify participants into pain sub-groups and predict who will respond best to certain pain treatments in participants with painful peripheral neuropathy. The analgesic effect is evaluated by measuring pain intensity and Patient Global Impression of Change (PGIC). This study is a 3-period cross-over trial. This means researchers will compare 3 different drugs (pregabalin, duloxetine, and placebo) over a period of 19 weeks. Participants will: * Undergo a quantitative sensory testing (QST) exam. * Provide a blood sample. * Complete questionnaires on the computer. * Take the study drug as instructed.

Painful Peripheral NeuropathyDiabetic Peripheral Neuropathic Pain (DPN)Chemotherapy Induced Peripheral Neuropathy (CIPN)+1 more

University of Rochester190 participantsStarted Jan 2026

Boston, Massachusetts, United States • New York, New York, United States • Rochester, New York, United States +4 more locations

Tovorafenib for Treatment of Craniopharyngioma in Children and Young Adults

SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy.

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