Kidney Disease Clinical Trials

Showing 961-980 of 3,346 trials

Terlipressin for HRS-AKI in Liver Transplant Candidates (INFUSE)

NCT04460560

Hepatorenal syndrome-acute kidney injury (HRS-AKI), a potentially reversible renal failure, is a serious, rapidly progressing, often fatal, complication of decompensated cirrhosis. Terlipressin is a synthetic vasopressin analogue that acts as a systemic vasoconstrictor via the vascular vasopressin V1 receptors. In HRS-AKI patients the strong V1 receptor-mediated vasoconstrictor activity of terlipressin, particularly in the splanchnic area, increases effective intravascular volume and mean arterial pressure (MAP), ameliorates renin-angiotensin-aldosterone system and sympathetic nervous system hyperactivity, and improves renal blood flow. The INFUSE trial will evaluate the use of continuous terlipressin infusion in patients on the liver transplant waiting list with HRS-AKI.

Hepatorenal Syndrome

University of Pennsylvania50 participantsStarted Dec 2020

San Francisco, California, United States • Atlanta, Georgia, United States • Boston, Massachusetts, United States +4 more locations

Active Not Recruiting

HeAlth-data Register sTudies of Risk and Outcomes in Cardiac Surgery

NCT02276950

The overall project aim is to study risk and outcomes following cardiac surgery by cross-linking high-quality national Swedish health-data registers for population-based investigations of individual level clinically relevant patient data.

Cardiovascular DiseasesKidney DiseasesDepression+1 more

Ulrik Sartipy, MD, PhD150,000 participantsStarted Jan 2011

Terlipressin for HRS-AKI in Liver Transplant Candidates (INFUSE)

HeAlth-data Register sTudies of Risk and Outcomes in Cardiac Surgery

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