Hypertension Clinical Trials

Showing 2581-2600 of 3,009 trials

Three Month Efficacy/Safety Study With a 3-Month Safety Extension of Brinzolamide 1%/Brimonidine 0.2% vs. Brinzolamide 1% or Brimonidine 0.2%

NCT01297920

The purpose of this study was to evaluate the safety and efficacy of a new ophthalmic suspension (Brinz/Brim) in lowering intraocular pressure (IOP) relative to its individual active components in subjects with open-angle glaucoma and/or ocular hypertension.

Open-Angle GlaucomaOcular Hypertension

Alcon Research1,062 participantsStarted Mar 2011

TERMINATEDPhase 2

Safety and Efficacy of Brinzolamide/Brimonidine Fixed Combination

NCT00961649

The purpose of this study was to compare the safety and intraocular pressure (IOP)-lowering efficacy of a new fixed combination of brinzolamide/brimonidine (Brinz/Brim) to: * its individual components (Brinz and Brim), and * the concomitant administration of Brinz and Brim (Brinz+Brim).

Open-Angle GlaucomaOcular Hypertension

Alcon Research195 participantsStarted Oct 2009

COMPLETEDPhase 4

The Effect of a Peroxisome Proliferator-activated Receptor (PPAR) Alpha Agonist on Cytochrome P450 (CYP) Monooxygenase Activity in Humans

NCT00872599

The hypothesis is to test to see if the drug fenofibrate will increase important chemicals in the body and specifically in the kidney, help to rid the body of salt by the kidneys, decrease blood pressure and improve insulin sensitivity during high-salt intake in individuals with hypertension.

Hypertension

Vanderbilt University75 participantsStarted Sep 2009

Nashville, Tennessee, United States

UNKNOWNPhase 1/2

Influence of Catheter-based Renal Denervation in Diseases With Increased Sympathetic Activity

NCT01888315

The study is aiming to document the long-term safety and effectiveness of renal denervation in patients with hypertension and other diseases characterized by elevated sympathetic drive. Catheter-based renal denervation will be performed using CE marked, percutaneous, systems.

HypertensionHeart FailureChronic Kidney Disease+2 more

University Hospital, Saarland1,000 participantsStarted Jan 2011

Homburg/Saar, Germany

Three Month Efficacy/Safety Study With a 3-Month Safety Extension of Brinzolamide 1%/Brimonidine 0.2% vs. Brinzolamide 1% or Brimonidine 0.2%

Safety and Efficacy of Brinzolamide/Brimonidine Fixed Combination

The Effect of a Peroxisome Proliferator-activated Receptor (PPAR) Alpha Agonist on Cytochrome P450 (CYP) Monooxygenase Activity in Humans

Influence of Catheter-based Renal Denervation in Diseases With Increased Sympathetic Activity

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