Hypertension Clinical Trials

Showing 2381-2400 of 3,009 trials

Study of the Relationships Between Refractory Hypertension, Overweight/Obesity and Sleep Apnea Syndrome

NCT00746902

The purpose of the study is to investigate the links between blood pressure (BP), overweight or obesity, and sleep apnea syndrome (SAS), by studying a large cohort of subjects suffering from refractory hypertension. Primary objective * To compare plasmatic leptin levels in patients suffering from refractory hypertension depending on whether or not they experience SAS. Secondary objectives * To ascertain what determines the difference in plasmatic leptin concentrations in patients suffering from refractory hypertension depending on whether or not they experience SAS. * To characterise BP readings (from clinical and ambulatory (ABPM) measurements) in patients suffering from refractory hypertension depending on whether or not they experience SAS. * To characterise metabolic parameters (lipids, glycaemia, adiponectin) and sympathetic nervous system effectors (adrenaline, noradrenaline and metanephrines) in patients suffering from refractory hypertension depending on whether or not they experience SAS. * To characterise BP readings, metabolic parameters and sympathetic nervous system effectors in patients suffering from refractory hypertension according to the severity of the SAS (in those who experience this problem). * To study, in patients with both SAS and refractory hypertension, the impact of nasal continuous positive airway pressure (CPAP) treatment on BP readings, metabolic parameters and sympathetic nervous system effectors, by comparing those who are compliant with the CPAP regimen with those who are non-compliant.

Refractory Hypertension

University Hospital, Grenoble62 participantsStarted Jun 2008

Grenoble, France

COMPLETEDNA

Hypothermia to Prevent High Intracranial Pressure in Patients With Acute Liver Failure

NCT00670124

Treatment options in patients with high intracranial pressure due to acute liver failure are limited. This study intends to evaluate the effect of prophylactic hypothermia on preventing high intracranial pressure and compromised cerebral oxidative metabolism.

Acute Liver FailureIntracranial Hypertension

Rigshospitalet, Denmark50 participantsStarted Jan 2005

Chicago, Illinois, United States • Copenhagen, Denmark • Birmingham, United Kingdom +1 more locations

Study of the Relationships Between Refractory Hypertension, Overweight/Obesity and Sleep Apnea Syndrome

Hypothermia to Prevent High Intracranial Pressure in Patients With Acute Liver Failure

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